Neuroprotective Effect of Ginseng against Alteration of Calcium Binding Proteins Immunoreactivity in the Mice Hippocampus after Radiofrequency Exposure
Figure 3
Photomicrograph of parvalbumin (PV) immunoreactivity (IR) in coronal sections through the hippocampal subfields of sham control (SC) (a, d, g), radiofrequency-exposed (E1.6) (b, e, h), and ginseng-treated (G1.6) (c, f, i) groups. Significant decrement of PV IR was observed in the E1.6 when compared with SC and G1.6 (a–i). PV immunopositive neurons were observed in SO and SP layers (a–c) which were very faintly labeled in E1.6 (c). PV immunoreactive fibers were noted to be running perpendicularly in SR. Various highly PV positive neurons along with dendrites running through the ML were observed in the GL of DG. A marked loss of IR was noted in the granular layer of E1.6 (e) which was not noted in G1.6 (f). CA3 area revealed various PV immunoreactive fibers along with few neurons distributed throughout the subfields. Decrease in IR was noted in E1.6 (h) as compared with SC (g) and G1.6 (i). SO: stratum oriens; SP: stratum pyramidale; SR: stratum radiatum; SLM: stratum lacunosum moleculare; SL: stratum lucidum; ML: molecular layer; GL: granular layer; PL: polymorphic layer. Scale bar = 100 μm.
