Phytoestrogen α-Zearalanol Attenuates Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells
Figure 8
Pretreatment with α-ZAL enhanced the expression of prosurvival protein Bcl-XL in homocysteine-challenged HUVECs (immunohistochemistry staining, only showing the picture of the highest concentration 10−6 mol/L). The expression of prosurvival protein Bcl-XL was significantly decreased after treatment with 500 μmol/L homocysteine for 24 h. Pretreatment with α-ZAL could enhance the expression of Bcl-XL. Data were presented as mean ± SD. versus Vehicle, versus Hcy alone. α-ZAL: α-zearalanol; 17β-E2: 17β-estradiol; Hcy: homocysteine.
