Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow

Figure 2

Kinetic of effect of PHZ-induced hemolysis on the mobilization of SKL cells and CFU-GM clonogenic progenitors. C57Bl/6 mice (10 mice per group) were sacrificed 1, 6, and 24 h after injection of PHZ (40 mg/kg i.p.). Control animals were injected with saline (0.9%). (a) shows the number of Sca-1⁺Kit⁺Lin⁻ (SKL) HSPCs circulating in PB (*𝑃<0.01) and (b) shows the number of clonogenic CFU-GM progenitors circulating in PB (*𝑃<0.01).

(a)

(b)