Sphingosine-1-phosphate-Mediated Mobilization of Hematopoietic Stem/Progenitor Cells during Intravascular Hemolysis Requires Attenuation of SDF-1-CXCR4 Retention Signaling in Bone Marrow
Figure 3
PHZ-induced mobilization of HSPCs is significantly potentiated after administration of AMD3100. The numbers of circulating CFU-GM able to grow colonies in methylcellulose cultures isolated from control, PHZ-, AMD3100-, and PHZ + AMD3100-injected C57Bl/6 mice are shown. The data are combined from two different experiments with 10 animals each. *.