Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 1

Design summary of experimental design.

(a)

Study type	Initial design	Center points	Design model	Runs	Blocks
Factorial	Full Factorial	0	2FI	9	No Blocks

(b)

Factor	Name	Units	Type	Low Actual	High Actual	Levels
𝐴	Alginate	%w/w	Categoric	1%	4%	3
𝐵	Acrycoat E30D	%w/w	Categoric	0%	4%	3

(c)

Response	Name	Units	Observn.	Analysis	Min.	Max.	Mean	SD	Ratio
Y1	𝐾0	mg/hr	9	Factorial	8.89	11.47	10.64	0.82	1.29
Y2	𝑋120	mg	9	Factorial	8.00	37.34	22.51	10.7	4.67
Y3	𝑡80	hr	9	Factorial	4.50	9.30	7.12	1.47	2.07
Y4	𝑛		9	Factorial	0.60	1.79	1.01	0.37	3.00

The design matrix Evaluation for factorial 2FI model.
Degrees of freedom (dF) for evaluation, model: 8, residuals: 0, lack of fit: 0, pure error: 0, and total: 9.