Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 10

Results of the in vivo parameters studied for both standard (S) and test (T) samples after 5 and 24 hours.

Sl. no.	Parameter	Standard sample; (Lasix tablet)		Test sample; micropellets (F9)
		5th hour	24th hour	5th hour	24th hour
1	Lipschitz quotient for urine volume	4.00	4.63	5.45	7.02*
2	% Increase in volume of collected urine	300.0	444.5	362.5	602.1*
3	Lipschitz quotient for Na+ excretion	5.78	2.17	6.31	4.00*
4	Lipschitz quotient for K+ excretion	1.27	1.61	1.60	4.26

∗Indicates (𝑃<0.05) 𝑛=5.