Table 2: Full 32 factorial design for the formulation of frusemide loaded calcium alginate micropellets.

Batch no./formulation codeSodium alginateAcrycoat E30D

F1
F20
F3+
F40
F500
F60+
F7+
F8+0
F9++

LevelSodium alginate (%w/w)Acrycoat E30D (%w/w)

+4.04.0
02.02.0
1.00.0

Constants: calcium chloride concentration—5%w/v, drug loading concentrations—30%w/w.