Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 2

Full 3² factorial design for the formulation of frusemide loaded calcium alginate micropellets.

Batch no./formulation code	Sodium alginate	Acrycoat E30D
F1	−	−
F2	−	0
F3	−	+
F4	0	−
F5	0	0
F6	0	+
F7	+	−
F8	+	0
F9	+	+
Level	Sodium alginate (%w/w)	Acrycoat E30D (%w/w)
+	4.0	4.0
0	2.0	2.0
−	1.0	0.0

Constants: calcium chloride concentration—5%w/v, drug loading concentrations—30%w/w.