Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 4

Summary of ANOVA for the response parameters.

Source	Sum of squares	Degree of freedom dF	Mean square	𝐹 value	𝑃 value; prob. > 𝐹	Effect
For “𝐾0”
Model	5.91	5	1.18	40.21	0.0060	significant
𝐴: alginate %w/w	3.13	1	3.13	106.59	0.0019
𝐵: acrycoat E30D %w/w	0.83	1	0.84	28.70	0.0127
𝐴𝐵	0.23	1	0.23	7.77	0.0685
𝐴^2	0.97	1	0.97	32.96	0.0105
𝐵^2	1.875𝐸−004	1	1.875𝐸−004	6.379𝐸−003	0.9414
Residual	0.088	3	0.029
Correction total	6	8
For “𝑋120”
Model	1012.2	5	202.44	33.26	0.0079	significant
𝐴: alginate %w/w	558.39	1	558.39	91.74	0.0024
𝐵: acrycoat E30D %w/w	70.4	1	70.4	11.57	0.0424
𝐴𝐵	43.53	1	43.53	7.15	0.0754
𝐴^2	517.97	1	517.97	85.10	0.0027
𝐵^2	5.74	1	5.74	0.94	0.4032
Residual	18.26	3	6.09
Correction total	1030.46	8
For “𝑡80”
Model	19.15	5	3.83	38.12	0.0065	significant
𝐴: alginate %w/w	16.34	1	16.34	162.55	0.0010
𝐵: acrycoat E30D %w/w	1.99	1	1.99	19.76	0.0212
𝐴𝐵	2.176𝐸−003	1	2.176𝐸−003	0.03	0.8743
𝐴^2	2.63	1	2.63	26.12	0.0145
𝐵^2	0.014	1	0.014	0.14	0.7348
Residual	0.30	3	0.10
Correction total	19.46	8
For “𝑛”
Model	1.11	5	0.22	5.56	0.0943	Not significant
𝐴: alginate %w/w	0.33	1	0.33	8.38	0.0627
𝐵: acrycoat E30D %w/w	0.17	1	0.17	4.15	0.1345
𝐴𝐵	0.013	1	0.013	0.33	0.6043
𝐴^2	0.73	1	0.73	18.43	0.0232
𝐵^2	0.025	1	0.025	0.63	0.4864
Residual	0.12	3	0.04
Correction total	1.23	8

𝐴 and 𝐵 represent the main effects (factors); 𝐴² and 𝐵² are the quadratic effect; 𝐴𝐵 is the interaction effect.