Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 5

Correlation coefficients (𝑅²) of different plots for overall (0–9 hr) release kinetics of frusemide from prepared micropellets.

Kinetic models	Correlation coefficients (𝑅^2 values)
	Level (−1)			Level (0)			Level (+1)
	F1	F2	F3	F4	F5	F6	F7	F8	F9
Zero order	0.8091	0.8749	0.8949	0.9918	0.9931	0.9397	0.9918	0.9945	0.9945
First order	0.9240	0.9824	0.8916	0.8678	0.8265	0.8531	0.8328	0.8933	0.9498
Higuchi	0.9003	0.9495	0.9599	0.9653	0.9638	0.8666	0.9750	0.9644	0.9606
Hixson-Crowell	0.9400	0.9819	0.9911	0.9473	0.9314	0.9025	0.9303	0.9485	0.9756