Research Article
Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide
Table 6
Independent formulation variables and their responses.
| | Formulation code | Sodium alginate conc. %(w/w) | Acrycoat E30D conc. %(w/w) |
(mg/hr) | (mg) | (hr) | |
| | F1 | 1 | 0 | 10.865 | 34.95 | 4.5 | 1.7429 | | F2 | 1 | 2 | 10.209 | 37.34 | 5.2 | 1.7309 | | F3 | 1 | 4 | 10.299 | 37.341 | 6.1 | 1.4378 | | F4 | 2 | 0 | 9.3247 | 16.988 | 7.2 | 1.8142 | | F5 | 2 | 2 | 9.0388 | 16.183 | 7.6 | 2.3807 | | F6 | 2 | 4 | 7.9428 | 8.001 | 7.8 | 1.8064 | | F7 | 4 | 0 | 7.5642 | 23.173 | 8 | 1.6173 | | F8 | 4 | 2 | 6.9212 | 17.382 | 8.4 | 1.6074 | | F9 | 4 | 4 | 6.1069 | 11.194 | 9.3 | 1.5608 |
|
|
