Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 7

Korsmeyer-Peppas model fitting release rate constants (𝐾_KP), correlation coefficient (𝑅²), and release exponent (𝑛) of frusemide from micropellets with different levels of alginate level (−1, 0, and +1).

Korsmeyer-Peppas model	Overall release (0–9 hr)			PHASE I (0–2 hr)			PHASE II (2–9 hr)
Formulation code	𝐾KP	𝑅^2	𝑛	𝐾KP I	𝑅^2 I	𝑛 I	𝐾KP II	𝑅^2 II	𝑛 II
F1	0.6731	0.7589	1.7429	0.7173	0.8535	3.6857	1.4996	0.7718	0.5952
F2	0.6529	0.7663	1.7309	0.7107	0.8682	3.7106	1.4664	0.8925	0.6015
F3	0.8685	0.7749	1.4378	0.9114	0.8359	2.96	1.4686	0.9026	0.6005
F4	0.4384	0.8909	1.8142	0.4954	0.895	3.1443	0.9029	0.9924	1.1637
F5	0.0197	0.7984	2.3807	0.1278	0.8487	4.8791	0.8831	0.9935	1.1705
F6	0.3049	0.9127	1.8064	0.3878	0.7992	2.5957	0.3002	0.9606	1.7854
F7	0.567	0.9004	1.6173	0.6205	0.9558	2.8874	1.0778	0.9844	0.9125
F8	0.5268	0.9177	1.6074	0.5699	0.9341	2.6683	0.9295	0.995	1.0477
F9	0.4982	0.969	1.5608	0.5086	0.9527	2.0875	0.719	0.9928	1.2522