Table 7: Korsmeyer-Peppas model fitting release rate constants ( ), correlation coefficient ( ), and release exponent ( ) of frusemide from micropellets with different levels of alginate level (−1, 0, and +1).

Korsmeyer-Peppas model Overall release (0–9 hr) PHASE I (0–2 hr) PHASE II (2–9 hr)
Formulation code I I I II II II

F1 0.6731 0.7589 1.7429 0.7173 0.8535 3.6857 1.4996 0.7718 0.5952
F2 0.6529 0.7663 1.7309 0.7107 0.8682 3.7106 1.4664 0.8925 0.6015
F3 0.8685 0.7749 1.4378 0.9114 0.8359 2.96 1.4686 0.9026 0.6005
F4 0.4384 0.8909 1.8142 0.4954 0.895 3.1443 0.9029 0.9924 1.1637
F5 0.0197 0.7984 2.3807 0.1278 0.8487 4.8791 0.8831 0.9935 1.1705
F6 0.3049 0.9127 1.8064 0.3878 0.7992 2.5957 0.3002 0.9606 1.7854
F7 0.567 0.9004 1.6173 0.6205 0.9558 2.8874 1.0778 0.9844 0.9125
F8 0.5268 0.9177 1.6074 0.5699 0.9341 2.6683 0.9295 0.995 1.0477
F9 0.4982 0.969 1.5608 0.5086 0.9527 2.0875 0.7190.99281.2522