Research Article
Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide
Table 8
Lipschitz test values of the collected urine sample.
| | Sl. no. | Group | Treatment |
Mean volume of urine collected (mL) |
Lipschitz value
(T or S/C) |
% Increase in Volume of Urine
| | 5th hour (mL) | 24th hour (mL) | 5th hour | 24th hour | 5th hour (%) | 24th hour (%) |
| 1
2
3
4
5 | Control (C) | Normal saline
5 mL/100 g body wt. | | | 1.00 | 1.00 | — | — |
| 6
7
8
9
10 | Standard (S) | Pure frusemide 50 mg/kg p.o. | | | 4.00 | 4.63 | 300.0 | 444.5 |
| 11
12
13
14
15 | Test (T) | Frusemide micropellets
50 mg/kg p.o. | | | 5.45 | 7.02 | 362.5 | 602.1* |
|
|
Values are expressed ± SEM
Indicates ().
|
