Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma

Figure 3

Tumour necrosis factor receptor-2 (TNFR2) mediated cellular responses in organ cultures of clear cell renal carcinoma (ccRCC). Treatment of cultures with a TNFR2-selective mutein induce coordinated activation and phosphorylation of endothelial/epithelial nonreceptor tyrosine kinase (Etk^p40) and vascular endothelial growth factor receptor-2 (VEGFR2^p1054–1059) in malignant tubular epithelial cells (arrows) (a–i), promoting cell cycle entry (j), indicated by nuclei staining for phospho-Histone H3^S10 (H3^pS10) and NFκB^p65 activation (k).

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