About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 821310, 11 pages
http://dx.doi.org/10.1155/2013/821310
Review Article

Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma

1Department of Nephrology, First Hospital of China Medical University, Shenyang, China
2Department of Medicine, Cambridge University NHS Trust Hospitals, Addenbrooke’s Hospital, P.O. Box 157, Level 5, Hill’s Road, Cambridge CB2 0QQ, UK

Received 25 August 2013; Revised 15 October 2013; Accepted 17 October 2013

Academic Editor: Shin Maeda

Copyright © 2013 Jun Wang and Rafia S. Al-Lamki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Hehlgans and K. Pfeffer, “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games,” Immunology, vol. 115, no. 1, pp. 1–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Kriegler, C. Perez, K. DeFay, I. Albert, and S. D. Lu, “A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF,” Cell, vol. 53, no. 1, pp. 45–53, 1988. View at Scopus
  3. W. Fiers, “Tumor necrosis factor: characterization at the molecular, cellular and in vivo level,” FEBS Letters, vol. 285, no. 2, pp. 199–212, 1991. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Rothe, G. Gehr, H. Loetscher, and W. Lesslauer, “Tumor necrosis factor receptors-structure and function,” Immunologic Research, vol. 11, no. 2, pp. 81–90, 1992. View at Scopus
  5. P. Vandenabeele, W. Declercq, D. Vercammen et al., “Functional characterization of the human tumor necrosis factor receptor p75 in a transfected rat/mouse T cell hybridoma,” Journal of Experimental Medicine, vol. 176, no. 4, pp. 1015–1024, 1992. View at Scopus
  6. B. B. Aggarwal, “Signalling pathways of the TNF superfamily: a double-edged sword,” Nature Reviews Immunology, vol. 3, no. 9, pp. 745–756, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Bradley, S. Thiru, and J. S. Pober, “Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells,” American Journal of Pathology, vol. 146, no. 1, pp. 27–32, 1995. View at Scopus
  8. R. S. Al-Lamki, J. Wang, J. N. Skepper, S. Thiru, J. S. Pober, and J. R. Bradley, “Expression of tumor necrosis factor receptors in normal kidney and rejecting renal transplants,” Laboratory Investigation, vol. 81, no. 11, pp. 1503–1515, 2001. View at Scopus
  9. L. A. Tartaglia, D. V. Goeddel, C. Reynolds et al., “Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor,” Journal of Immunology, vol. 151, no. 9, pp. 4637–4641, 1993. View at Scopus
  10. R. S. Al-Lamki, A. P. Brookes, J. Wang et al., “TNF receptors differentially signal and are differentially expressed and regulated in the human heart,” American Journal of Transplantation, vol. 9, no. 12, pp. 2679–2696, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. L. Kelly, M. Wang, P. R. Crisostomo et al., “TNF receptor 2, not TNF receptor 1, enhances mesenchymal stem cell-mediated cardiac protection following acute ischemia,” Shock, vol. 33, no. 6, pp. 602–607, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. R. S. Al-Lamki, W. Lu, J. Wang et al., “TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-kit cardiac stem cells in ischemic heart disease,” Stem Cells, vol. 31, no. 9, pp. 1881–1892, 2013. View at Publisher · View at Google Scholar
  13. S. L. Montgomery, M. A. Mastrangelo, D. Habib et al., “Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain,” American Journal of Pathology, vol. 179, no. 4, pp. 2053–2070, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. J. R. Patel, J. L. Williams, M. M. Muccigrosso et al., “Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS,” Acta Neuropathologica, vol. 124, no. 6, pp. 847–860, 2012.
  15. L. A. Tartaglia, R. F. Weber, I. S. Figari, C. Reynolds, M. A. Palladino Jr., and D. V. Goeddel, “The two different receptors for tumor necrosis factor mediate distinct cellular responses,” Proceedings of the National Academy of Sciences of the United States of America, vol. 88, no. 20, pp. 9292–9296, 1991. View at Scopus
  16. R. S. Al-Lamki, T. J. Sadler, J. Wang et al., “Tumor necrosis factor receptor expression and signaling in renal cell carcinoma,” American Journal of Pathology, vol. 177, no. 2, pp. 943–954, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. B. Depuydt, G. van Loo, P. Vandenabeele, and W. Declercq, “Induction of apoptosis by TNF receptor 2 in a T-cell hybridoma is FADD dependent and blocked by caspase-8 inhibitors,” Journal of Cell Science, vol. 118, no. 3, pp. 497–504, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. R. S. Al-Lamki, J. Wang, P. Vandenabeele et al., “TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury,” The FASEB Journal, vol. 19, no. 12, pp. 1637–1645, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Grell, F. M. Becke, H. Wajant, D. N. Mannel, and P. Scheurich, “TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1,” European Journal of Immunology, vol. 28, no. 1, pp. 257–263, 1998.
  20. X. Chen and J. J. Oppenheim, “TNF-α: an activator of CD4+FoxP3+TNFR2+ regulatory T cells,” Current Directions in Autoimmunity, vol. 11, pp. 119–134, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. X. Chen and J. J. Oppenheim, “The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4+FoxP3+ regulatory T cells,” Immunology, vol. 133, no. 4, pp. 426–433, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. H.-U. Meier-Kriesche, J. D. Schold, T. R. Srinivas, and B. Kaplan, “Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era,” American Journal of Transplantation, vol. 4, no. 3, pp. 378–383, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. D. Morel, E. Normand, C. Lemoine et al., “Tumor necrosis factor alpha in human kidney transplant rejection—analysis by in situ hybridization,” Transplantation, vol. 55, no. 4, pp. 773–777, 1993. View at Scopus
  24. P. F. A. Mulders, “Renal cell carcinoma,” World Journal of Urology, vol. 26, no. 2, p. 113, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. H. T. Cohen and F. J. McGovern, “Renal-cell carcinoma,” The New England Journal of Medicine, vol. 353, no. 23, pp. 2477–2490, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Berger, R. Brandina, M. A. Atalla et al., “Laparoscopic radical nephrectomy for renal cell carcinoma: oncological outcomes at 10 years or more,” Journal of Urology, vol. 182, no. 5, pp. 2172–2176, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. N. K. Janzen, H. L. Kim, R. A. Figlin, and A. S. Belldegrun, “Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease,” The Urologic Clinics of North America, vol. 30, no. 4, pp. 843–852, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Piselli, D. Serraino, G. P. Segoloni et al., “Risk of de novo cancers after transplantation: results from a cohort of 7217 kidney transplant recipients, Italy 1997-2009,” European Journal of Cancer, vol. 49, no. 2, pp. 336–344, 2013.
  29. A. Rocha, J. Malheiro, I. Fonseca et al., “Noncutaneous neoplasms after kidney transplantation: analysis at single center,” Transplantation Proceedings, vol. 45, no. 3, pp. 1102–1105, 2013.
  30. A. Tuzuner, F. Cakir, C. Akyol et al., “Nephron-sparing surgery for renal cell carcinoma of the allograft after renal transplantation: report of two cases,” Transplantation Proceedings, vol. 45, no. 3, pp. 958–960, 2013.
  31. L. A. Tartaglia, D. Pennica, and D. V. Goeddel, “Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor,” The Journal of Biological Chemistry, vol. 268, no. 25, pp. 18542–18548, 1993. View at Scopus
  32. E. C. Ledgerwood, J. S. Pober, and J. R. Bradley, “Recent advances in the molecular basis of TNF signal transduction,” Laboratory Investigation, vol. 79, no. 9, pp. 1041–1050, 1999. View at Scopus
  33. M. Fotin-Mleczek, F. Henkler, D. Samel et al., “Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8,” Journal of Cell Science, vol. 115, part 13, pp. 2757–2770, 2002.
  34. M. Rothe, V. Sarma, V. M. Dixit, and D. V. Goeddel, “TRAF2-Mediated activation of NF-κB by TNF receptor 2 and CD40,” Science, vol. 269, no. 5229, pp. 1424–1427, 1995. View at Scopus
  35. Y. Zhao, D. B. Conze, J. A. Hanover, and J. D. Ashwell, “Tumor necrosis factor receptor 2 signaling induces selective c-IAP1-dependent ASK1 ubiquitination and terminates mitogen-activated protein kinase signaling,” The Journal of Biological Chemistry, vol. 282, no. 11, pp. 7777–7782, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. W. Ji, Y. Li, T. Wan et al., “Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 32, no. 9, pp. 2271–2279, 2012.
  37. M. Karin, “The regulation of AP-1 activity by mitogen-activated protein kinases,” Philosophical Transactions of the Royal Society B, vol. 351, no. 1336, pp. 127–134, 1996. View at Scopus
  38. V. Haridas, B. G. Darnay, K. Natarajan, R. Heller, and B. B. Aggarwal, “Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-κB activation, and c-Jun kinase activation,” Journal of Immunology, vol. 160, no. 7, pp. 3152–3162, 1998. View at Scopus
  39. O. J. Jupp, S. M. McFarlane, H. M. Anderson et al., “Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways,” Biochemical Journal, vol. 359, part 3, pp. 525–535, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. A. P. Grech, S. Gardam, T. Chan et al., “Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site,” The Journal of Biological Chemistry, vol. 280, no. 36, pp. 31572–31581, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Rothe, S. C. Wong, W. J. Henzel, and D. V. Goeddel, “A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor,” Cell, vol. 78, no. 4, pp. 681–692, 1994. View at Publisher · View at Google Scholar · View at Scopus
  42. F. X. Pimentel-Muiños and B. Seed, “Regulated commitment of TNF receptor signaling: a molecular switch for death or activation,” Immunity, vol. 11, no. 6, pp. 783–793, 1999. View at Scopus
  43. T. W. Mak and W. C. Yeh, “Signaling for survival and apoptosis in the immune system,” Arthritis Research, vol. 4, supplement 3, pp. 243–252, 2002.
  44. L. A. Bruggeman, P. E. Drawz, N. Kahoud, K. Lin, L. Barisoni, and P. J. Nelson, “TNFR2 interposes the proliferative and NF-B-mediated inflammatory response by podocytes to TNF-α,” Laboratory Investigation, vol. 91, no. 3, pp. 413–425, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. J. H. Li and J. S. Pober, “The cathepsin B death pathway contributes to TNF plus INF-γ-mediated human endothelial injury,” Journal of Immunology, vol. 175, no. 3, pp. 1858–1866, 2005. View at Scopus
  46. P. Vandenabeele, L. Galluzzi, T. Vanden Berghe, and G. Kroemer, “Molecular mechanisms of necroptosis: an ordered cellular explosion,” Nature Reviews Molecular Cell Biology, vol. 11, no. 10, pp. 700–714, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. S. Pan, P. An, R. Zhang, X. He, G. Yin, and W. Min, “Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis,” Molecular and Cellular Biology, vol. 22, no. 21, pp. 7512–7523, 2002. View at Publisher · View at Google Scholar · View at Scopus
  48. M. Hummel, S. M. Kurian, S. Lin et al., “Intragraft TNF receptor signaling contributes to activation of innate and adaptive immunity in a renal allograft model,” Transplantation, vol. 87, no. 2, pp. 178–188, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. T. Dhaouadi, I. Sfar, R. Bardi et al., “Cytokine gene polymorphisms in kidney transplantation,” Transplantation Proceedings, vol. 45, no. 6, pp. 2152–2157, 2013.
  50. L. G. Wramner, J. Norrby, M. Hahn-Zoric et al., “Impaired kidney graft survival is associated with the TNF-α genotype,” Transplantation, vol. 78, no. 1, pp. 117–121, 2004. View at Publisher · View at Google Scholar · View at Scopus
  51. S. Dmitrienko, D. I. Hoar, R. Balshaw, and P. A. Keown, “Immune response gene polymorphisms in renal transplant recipients,” Transplantation, vol. 80, no. 12, pp. 1773–1782, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. S. W. Reinhold, R. H. Straub, B. Krüger et al., “Elevated urinary sVCAM-1, IL6, sIL6R and TNFR1 concentrations indicate acute kidney transplant rejection in the first 2 weeks after transplantation,” Cytokine, vol. 57, no. 3, pp. 379–388, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. U. Hoffmann, T. Bergler, M. Rihm et al., “Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection,” American Journal of Transplantation, vol. 9, no. 4, pp. 675–686, 2009. View at Publisher · View at Google Scholar · View at Scopus
  54. S. M. Santee and L. B. Owen-Schaub, “Human tumor necrosis factor receptor p75/80 (CD120b) gene structure and promoter characterization,” The Journal of Biological Chemistry, vol. 271, no. 35, pp. 21151–21159, 1996. View at Publisher · View at Google Scholar · View at Scopus
  55. G. Ramesh and W. B. Reeves, “Inflammatory cytokines in acute renal failure,” Kidney International, Supplement, vol. 66, no. 91, pp. S56–S61, 2004. View at Scopus
  56. R. S. Al-Lamki, J. Wang, A. M. Tolkovsky et al., “TL1A both promotes and protects from renal inflammation and injury,” Journal of the American Society of Nephrology, vol. 19, no. 5, pp. 953–960, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. I. Puga, B. Lainez, J. M. Fernández-Real et al., “A polymorphism in the 3′ untranslated region of the gene for tumor necrosis factor receptor 2 modulates reporter gene expression,” Endocrinology, vol. 146, no. 5, pp. 2210–2220, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. M. Uribe-Herranz, S. R. Casinghino, L. Bosch-Presegué, W. L. Fodor, and C. Costa, “Identification of soluble and membrane-bound isoforms of porcine tumor necrosis factor receptor 2,” Xenotransplantation, vol. 18, no. 2, pp. 131–146, 2011. View at Publisher · View at Google Scholar · View at Scopus
  59. M. S. Sabatine, T. Laufer, L. H. Glimcher, M. Widmer, H. Winn, and H. Auchincloss Jr., “Delayed rejection of soluble tumor necrosis factor receptor-secreting tumor allografts,” Transplantation, vol. 65, no. 1, pp. 113–120, 1998. View at Publisher · View at Google Scholar · View at Scopus
  60. K. J. van Zee, T. Kohno, E. Fischer, C. S. Rock, L. L. Moldawer, and S. F. Lowry, “Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor α in vitro and in vivo,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 11, pp. 4845–4849, 1992. View at Publisher · View at Google Scholar · View at Scopus
  61. S. Bruneau, C. B. Woda, K. P. Daly et al., “Key features of the intragraft microenvironment that determine long-term survival following transplantation,” Frontiers in Immunology, vol. 3, article 54, 2012.
  62. C. J. Burton, C. Combe, J. Walls, and K. P. G. Harris, “Secretion of chemokines and cytokines by human tubular epithelial cells in response to proteins,” Nephrology Dialysis Transplantation, vol. 14, no. 11, pp. 2628–2633, 1999. View at Scopus
  63. H. Robertson, J. Wheeler, A. R. Morley, T. A. Booth, D. Talbot, and J. A. Kirby, “β-chemokine expression and distribution in paraffin-embedded transplant renal biopsy sections: analysis by scanning laser confocal microscopy,” Histochemistry and Cell Biology, vol. 110, no. 2, pp. 207–213, 1998. View at Publisher · View at Google Scholar · View at Scopus
  64. E. Thorburn, L. Kolesar, E. Brabcova et al., “CXC and CC chemokines induced in human renal epithelial cells by inflammatory cytokines,” APMIS, vol. 117, no. 7, pp. 477–487, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Wang, Z. Li, R. Al-Lamki et al., “The role of tumor necrosis factor-α converting enzyme in renal transplant rejection,” American Journal of Nephrology, vol. 32, no. 4, pp. 362–368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  66. C. Adrain, M. Zettl, Y. Christova, N. Taylor, and M. Freeman, “Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE,” Science, vol. 335, no. 6065, pp. 225–228, 2012. View at Publisher · View at Google Scholar · View at Scopus
  67. R. Diller, G. Winde, S. Kötting, N. Senninger, K.-H. Dietl, and H.-U. Spiegel, “sTNF-RII: is it useful for the early diagnosis of rejection and for prognosis after renal transplantation?” Transplant International, vol. 15, no. 7, pp. 335–340, 2002. View at Publisher · View at Google Scholar · View at Scopus
  68. T.-S. Migone, J. Zhang, X. Luo et al., “TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator,” Immunity, vol. 16, no. 3, pp. 479–492, 2002. View at Publisher · View at Google Scholar · View at Scopus
  69. J. I. Lopez, “Renal tumors with clear cells. A review,” Pathology, Research and Practice, vol. 209, no. 3, pp. 137–146, 2013.
  70. G. Sethi, B. Sung, and B. B. Aggarwal, “TNF: a master switch for inflammation to cancer,” Frontiers in Bioscience, vol. 13, no. 13, pp. 5094–5107, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. B. B. Aggarwal, S. Shishodia, S. K. Sandur, M. K. Pandey, and G. Sethi, “Inflammation and cancer: how hot is the link?” Biochemical Pharmacology, vol. 72, no. 11, pp. 1605–1621, 2006. View at Publisher · View at Google Scholar · View at Scopus
  72. F. Balkwill, “TNF-α in promotion and progression of cancer,” Cancer and Metastasis Reviews, vol. 25, no. 3, pp. 409–416, 2006. View at Publisher · View at Google Scholar · View at Scopus
  73. F. Balkwill, “Tumor necrosis factor or tumor promoting factor?” Cytokine and Growth Factor Reviews, vol. 13, no. 2, pp. 135–141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. M.-J. Chuang, K.-H. Sun, S.-J. Tang et al., “Tumor-derived tumor necrosis factor-alpha promotes progression and epithelial-mesenchymal transition in renal cell carcinoma cells,” Cancer Science, vol. 99, no. 5, pp. 905–913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  75. B. Baştürk, I. Yavaşçaoǧlu, H. Vuruşkan, G. Göral, B. Oktay, and H. B. Oral, “Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma,” Cytokine, vol. 30, no. 1, pp. 41–45, 2005. View at Publisher · View at Google Scholar · View at Scopus
  76. B. Einollahi, “Malignancy after kidney transplantation,” Annals of Transplantation, vol. 17, no. 1, pp. 145–146, 2012. View at Scopus
  77. S. Aaltomaa, P. Lipponen, M. Ala-Opas, M. Eskelinen, and K. Syrjanen, “Prognostic value of Ki-67 expression in renal cell carcinomas,” European Urology, vol. 31, no. 3, pp. 350–355, 1997. View at Scopus
  78. T. Weber, M. Meinhardt, S. Zastrow, A. Wienke, S. Fuessel, and M. P. Wirth, “Immunohistochemical analysis of prognostic protein markers for primary localized clear cell renal cell carcinoma,” Cancer Investigation, vol. 31, no. 1, pp. 51–59, 2013.
  79. S. Ikemoto, K. Narita, N. Yoshida et al., “Effects of tumor necrosis factor alpha in renal cell carcinoma,” Oncology Reports, vol. 10, no. 6, pp. 1947–1955, 2003. View at Scopus
  80. M. Grell, “Tumor necrosis factor (TNF) receptors in cellular signaling of soluble and membrane-expressed TNF,” Journal of Inflammation, vol. 47, no. 1-2, pp. 8–17, 1995. View at Scopus
  81. H. Qi and M. Ohh, “The von Hippel-Lindau tumor suppressor protein sensitizes renal cell carcinoma cells to tumor necrosis factor-induced cytotoxicity by suppressing the nuclear factor-κB-dependent antiapoptotic pathway,” Cancer Research, vol. 63, no. 21, pp. 7076–7080, 2003. View at Scopus
  82. A. S. Al-Ansari, W. E. R. Ollier, J. Villarreal, J. Ordi, L.-S. Teh, and A. H. Hajeer, “Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus,” Tissue Antigens, vol. 55, no. 1, pp. 97–99, 2000. View at Publisher · View at Google Scholar · View at Scopus
  83. X. Guan, Z. Liao, H. Ma et al., “TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy,” BMC Cancer, vol. 11, article no. 447, 2011. View at Publisher · View at Google Scholar · View at Scopus
  84. T. Horiuchi, C. Kiyohara, H. Tsukamoto et al., “A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis,” Annals of the Rheumatic Diseases, vol. 66, no. 3, pp. 320–324, 2007. View at Publisher · View at Google Scholar · View at Scopus
  85. S. Mestiri, N. Bouaouina, S. B. Ahmed, and L. Chouchane, “A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma,” Cytokine, vol. 30, no. 4, pp. 182–187, 2005. View at Publisher · View at Google Scholar · View at Scopus
  86. A. Till, P. Rosenstiel, A. Krippner-Heidenreich et al., “The Met-196 → Arg variation of human Tumor Necrosis Factor Receptor 2 (TNFR2) affects TNF-α-induced apoptosis by impaired NF-κB signaling and target gene expression,” The Journal of Biological Chemistry, vol. 280, no. 7, pp. 5994–6004, 2005. View at Publisher · View at Google Scholar · View at Scopus
  87. P. C. Baer, J. Bereiter-Hahn, C. Missler et al., “Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells,” Cell Proliferation, vol. 42, no. 1, pp. 29–37, 2009. View at Publisher · View at Google Scholar · View at Scopus
  88. S. P. Sasi, X. Yan, H. Enderling, et al., “Breaking the “harmony” of TNF-alpha signaling for cancer treatment,” Oncogene, vol. 31, no. 37, pp. 4117–4127, 2012.
  89. O. Kemper, J. Derre, D. Cherif, H. Engelmann, D. Wallach, and R. Berger, “The gene for the type II (p75) tumor necrosis factor receptor (TNF-RII) is localized on band 1p36.2-p36.3,” Human Genetics, vol. 87, no. 5, pp. 623–624, 1991. View at Scopus
  90. B. R. Reeves and V. L. Pickup, “The chromosome changes in non-Burkitt lymphomas,” Human Genetics, vol. 53, no. 3, pp. 349–355, 1980. View at Scopus
  91. M. Benucci, G. Saviola, M. Manfredi, P. Sarzi-Puttini, and F. Atzeni, “Tumor necrosis factors blocking agents: analogies and differences,” Acta Bio-Medica, vol. 83, no. 1, pp. 72–80, 2012.
  92. C. Joyau, G. Veyrac, V. Dixneuf, and P. Jolliet, “Anti-tumour necrosis factor alpha therapy and increased risk of de novo psoriasis: is it really a paradoxical side effect? Clinical and experimental rheumatology,” vol. 30, no. 5, pp. 700–706, 2012.
  93. A. Wiens, R. Venson, C. J. Correr, M. F. Otuki, and R. Pontarolo, “Meta-analysis of the efficacy and safety of adalimumab, etanercept, and infliximab for the treatment of rheumatoid arthritis,” Pharmacotherapy, vol. 30, no. 4, pp. 339–353, 2010. View at Publisher · View at Google Scholar · View at Scopus
  94. Q. Javed and I. Murtaza, “Therapeutic potential of tumour necrosis factor-alpha antagonists in patients with chronic heart failure,” Heart, Lung & Circulation, vol. 22, no. 5, pp. 323–327, 2013.
  95. A. Pascher and J. Klupp, “Biologics in the treatment of transplant rejection and ischemia/reperfusion injury: new applications for TNFα inhibitors?” BioDrugs, vol. 19, no. 4, pp. 211–231, 2005. View at Publisher · View at Google Scholar · View at Scopus
  96. B. Scallon, A. Cai, N. Solowski et al., “Binding and functional comparisons of two types of tumor necrosis factor antagonists,” Journal of Pharmacology and Experimental Therapeutics, vol. 301, no. 2, pp. 418–426, 2002. View at Publisher · View at Google Scholar · View at Scopus
  97. M. Grell, E. Douni, H. Wajant et al., “The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor,” Cell, vol. 83, no. 5, pp. 793–802, 1995. View at Scopus
  98. L. Ban, J. Zhang, L. Wang, W. Kuhtreiber, D. Burger, and D. L. Faustman, “Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 36, pp. 13644–13649, 2008. View at Publisher · View at Google Scholar · View at Scopus
  99. M. B. Welborn III, K. van Zee, P. D. Edwards et al., “A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon,” Journal of Experimental Medicine, vol. 184, no. 1, pp. 165–171, 1996. View at Publisher · View at Google Scholar · View at Scopus