Oxidative Stress Induces Mitochondrial DNA Damage and Cytotoxicity through Independent Mechanisms in Human Cancer Cells
Figure 2
A new paradigm of oxidative injury in prostate cancer versus normal cells. Aggressive prostate cancer cells exhibit increased susceptibility to oxidant injury and DNA damage through independent mechanisms (a). See text for details. Immortalized epithelial cells are resistant to H2O2-induced cell toxicity but sensitive to oxidative DNA damage (b). The strong resistance is correlated to a lack of sustained production through NAD(P)H oxidases, while the sensitive mtDNA damage is due to direct infiltration of H2O2 and its derivative.
