Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract of Nyctanthes arbor-tristis Linn.

Table 1

Hot plate method: effects of methanolic extracts of Nyctanthes arbor-tristis stem barks and morphine on pain induced by hot plate method.

Group	Dose (mg/kg)	Reaction time (in sec)
		0 min	15 min	30 min	60 min	90 min
Control	—	4.05 ± 0.01	3.89 ± 0.16	4.02 ± 0.32	4.11 ± 0.02	3.78 ± 0.15
Standard	5 (i.p)	4.01 ± 0.12 a*	4.92 ± 0.18 a^@	7.15 ± 0.11 a^@	8.87 ± 0.12 a^@	10.41 ± 0.01 a^@
MENA250	250 (p.o)	3.68 ± 0.005 a^#b^#	4.25 ± 0.01 a*b^#	4.98 ± 0.12 a^#b^@	5.57 ± 0.17 a^@b^@	6.13 ± 0.20 a^@b^@
MENA500	500 (p.o)	4.03 ± 0.02 a*b*c^#	4.68 ± 0.05 a^#b*c*	6.33 ± 0.10 a^@b*c^@	7.18 ± 0.005 a^@b^@c^@	8.02 ± 0.12 a^@b^@c^@

Data are expressed as Mean ± SEM, 𝑛=6 animals in each group. One-way ANOVA was carried out using Turkey’s multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA₂₅₀, and MENA₅₀₀.
b: Standard versus MENA₂₅₀ and MENA₅₀₀.
c: MENA₂₅₀ versus MENA₅₀₀.
Symbols represent statistical significance: *𝑃<0.05, ^#𝑃<0.01, ^@𝑃<0.001.