Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract of Nyctanthes arbor-tristis Linn.

Table 4

Carrageenan-induced paw edema (acute model): effects of methanolic extracts of Nyctanthes arbor-tristis stem bark and diclofenac on carrageenan-induced paw edema in rats.

Group	Dose (mg/kg)	Paw volume increase (in mL)
		0 hr	1 hr	2 hr	3 hr	4 hr	5 hr
Control	—	0.63 ± 0.01	0.86 ± 0.03	1.12 ± 0.01	1.23 ± 0.005	1.28 ± 0.02	1.20 ± 0.12
Standard	100 (p.o)	0.61 ± 0.12 a*	0.72 ± 0.06 a*	0.80 ± 0.01 a^#	0.84 ± 0.04 a^@	0.78 ± 0.01 a^@	0.73 ± 0.01 a^@
MENA250	250 (p.o)	0.62 ± 0.01 a*b*	0.82 ± 0.10 a*b*	0.94 ± 0.03 a*b*	1.01 ± 0.01 a^@b^@	0.97 ± 0.06 a^@b^#	0.92 ± 0.02 a*b*
MENA500	500 (p.o)	0.61 ± 0.02 a*b*c^ns	0.78 ± 0.01 a*b*c*	0.90 ± .12 a*b*c*	0.95 ± 0.01 a^@b^#c*	0.89 ± 0.05 a^@b*c*	0.82 ± 0.01 a^#b*c*

Data are expressed as Mean ± SEM, 𝑛=6 animals in each group. One-way ANOVA was carried out using Turkey’s multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA₂₅₀, and MENA₅₀₀.
b: Standard versus MENA₂₅₀ and MENA₅₀₀.
c: MENA₂₅₀ versus MENA₅₀₀.
Symbols represent statistical significance: *𝑃<0.05, ^#𝑃<0.01, ^@𝑃<0.001.