Table 5: Rate of edema formation.

GroupDose (mg/kg)Increase in edema (%)
0 hr1 hr2 hr3 hr4 hr5 hr

Control36.25 ± 0.1177.32 ± 0.1496.43 ± 0.43103.14 ± 0.13100.41 ± 0.23
Standard100 (p.o)18.34 ± 0.34 a#31.12 ± 0.16 a#37.14 ± 0.41 a#27.34 ± 0.45 a#19.32 ± 0.34 a#
MENA250250 (p.o)25.12 ± 0.16 a#b@51.26 ± 0.13 a#b@62.32 ± 0.32 a#b@56.57 ± 0.22 a#b@48.43 ± 0.21 a#b@
MENA500500 (p.o)27.45 ± 0.17 a#b@c@47.32 ± 0.14 a#b@c@55.31 ± 0.43 a#b@c@45.42 ± 0.20 a#b@c@34.21 ± 0.24 a#b@c@

Data are expressed as Mean ± SEM, animals in each group. One-way ANOVA was carried out using Turkey’s multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA250, and MENA500.
b: Standard versus MENA250 and MENA500.
c: MENA250 versus MENA500.
Symbols represent statistical significance: * , # , @ , ns: nonsignificant.