Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
Table 2
Other macroscopic alterations in DNA-immunized dogs with chronic experimental Chagas disease.
Macroscopic pathological features at 11 months after infection (at the time of euthanizing)
Groups
Dogs/n (%)
Whitish areas in heart of fibrous consistency Abundant pericardial fluid Whitish areas in spleen
SS (mock-immunized) and pBK-CMV (empty plasmid)
5/7 (71%) 6/7 (86%)
Ascites Megaesophagus Left ventricular hypertrophy Thinning of the right ventricular wall Severe tricuspid endocarditis
pBK-CMV (empty plasmid)
1/7 (14%)
Heart with adhesions in trachea and pericardium Splenic thickened walls Whitish areas in spleen and heart