Immunization with a Neural-Derived Peptide Protects the Spinal Cord from Apoptosis after Traumatic Injury

<table>Reduction of apoptosis by A91 immunization as revealed by TUNEL assay in the injury site. Seven days after SC injury. (a) Rostral region 2 mm from injury epicenter. *Different from A91-immunized rats (<svg height="11.375" id="M37" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>; Mann-Whitney <svg height="11.4625" id="M38" style="vertical-align:-0.23206pt" version="1.1" viewbox="0 0 13.1 11.4625" width="13.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> test). (b) Caudal region 2 mm from injury epicenter. *Different from A91-immunized rats (<svg height="11.375" id="M39" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.875 11.375" width="66.875" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>; Mann-Whitney <svg height="11.4625" id="M40" style="vertical-align:-0.23206pt" version="1.1" viewbox="0 0 13.1 11.4625" width="13.1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> test). A91 immunization induced a significant reduction in apoptosis. Bars represent the mean ± SD of 4 rats.</table>

BioMed Research International

fig2

Figure 2

Figure 2: Immunization with a Neural-Derived Peptide Protects the Spinal Cord from Apoptosis after Traumatic Injury 