Class A 𝜷-Lactamases as Versatile Scaffolds to Create Hybrid Enzymes: Applications from Basic Research to Medicine

Figure 5

Schematic representations of the glycoprotein CD22 in a linear and U-shaped arrangement. In the linear arrangement, the three clusters forming the epitope are far away from each other whereas they are close in a U-shaped arrangement [8]. The residues involved in the complex with mab 8015 are clustered in cluster 1, 2, and 3 and are shown in light blue, red, and green, respectively. Figure adapted from Bannister et al. [8].