Development of a Novel System for Mass Spectrometric Analysis of Cancer-Associated Fucosylation in Plasma α1-Acid Glycoprotein
Figure 4
Mass spectra of AGP glycans isolated from followed up patients with advanced cancer. Patients with a poor prognosis, stage IV colon cancer with recurrence (a), rectal cancer with recurrence (b), and stage IIIA lung cancer (c). Purified AGP was prepared and labeled from 500 μL of plasma samples and an each aliquot (ca. one-fiftieth) was used for MS analysis. White and black triangles indicate defucosylated and fucosylated tri- and tetra-antennary glycans assigned, respectively. POD, postoperative days.
