Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [11C]KR31173
Table 3
Compartmental rate constants and parameters of ligand binding. , , , and represent compartmental rate constants, DVNS is the distribution volume of nonspecific binding, DVS is the distribution volume of specific binding, is ligand retention calculated from tissue activity, and is ligand retention calculated from the impulse response function. Further details of computations are described in the methods.
Convolution fit
Deconvolution fit
Group
K
1
k
2
K
3
k
4
DVNS
DVS
DVR
Y
ret (80 min)
K
1
k
2
K
3
k
4
DVNS
DVS
DVR
f
ret (80 min)
Mean IRa
1.113
0.357
0.193
0.013
2.968
15.270
5.808
0.170
0.720
0.411
0.101
0.013
1.633
7.604
5.383
0.099
(sd IR)a
0.731
0.131
0.040
0.003
1.058
0.844
2.830
0.056
0.523
0.146
0.019
0.002
0.665
0.653
2.844
0.047
Mean CLb
1.413
0.387
0.183
0.011
3.407
16.167
5.181
0.153
0.852
0.432
0.098
0.013
1.836
7.788
4.691
0.092
(sd CL)b
0.985
0.137
0.036
0.003
1.233
1.481
1.807
0.037
0.604
0.136
0.019
0.003
0.747
0.877
1.661
0.036
Mean Cc
0.985
0.246
0.212
0.013
3.959
15.902
4.168
0.136
0.591
0.319
0.130
0.017
1.849
7.267
4.255
0.087
(sd C)c
0.250
0.031
0.077
0.002
0.628
4.058
1.564
0.025
0.160
0.030
0.056
0.005
0.476
1.313
1.726
0.027
t (IR vs C)d
0.794
0.279
0.640
0.824
0.240
0.727
0.427
0.410
0.714
0.389
0.298
0.164
0.649
0.623
0.576
0.726
t (CL vs C)e
0.532
0.215
0.467
0.417
0.527
0.891
0.459
0.528
0.534
0.283
0.245
0.126
0.980
0.506
0.732
0.853
Mean and standard deviation values for aischemia followed by reperfusion, bcontralateral, and ccontrol kidneys.
dSimple t-test of the differences between kidneys with ischemia followed by reperfusion (IR) and controls. eSimple t-test of the differences between contralateral kidneys and controls. The differences are not significant ().
