Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [¹¹C]KR31173

Table 6

Effect of imaging time on the distribution volume ratio 𝑌_ret. The bias represented by the average % difference (for the 12 kidneys) between the actual 𝑌_ret and reference 𝑌_ret is acceptable (less than 10%) at time points 82.5 min or later. Loadings on factor 1 are acceptable (higher than 0.800) at all time points.

Time point (min)	42.5	47.5	52.5	57.5	62.5	72.5	72.5	77.5	82.5	87.5
Bias (%)	53	46	40	32	25	22	18	12	9	0
Factor 1	0.877	0.898	0.977	0.973	0.967	0.986	0.963	0.975	0.843	0.8573
Factor 2	0.453	0.423	−0.105	−0.068	−0.104	−0.116	−0.205	−0.102	−0.499	0.376