Table 1: Receptors for the peptide-based PET tracers [1114].

ReceptorsPeptideCancerLabeling

Somatostatin receptorSomatostatinNeuroendocrine tumors 68Ga-DOTA, 68Ga-NOTA, 64Cu-TETA, 64Cu-DOTA, 64Cu-NOTA, 64Cu-CB-TE2A, 18F-NFP, 18F-SFB, and so forth
Gastrin-releasing peptide receptor (GRPR)BombesinProstate cancer, breast cancer, Gastrointestinal stromal tumor
-integrinRGDBrain cancer, lung cancer, breast cancer, and so forth

Melanocortin 1 receptor (MC1R) -MSHMelanomas 18F-SFB, 68Ga-DOTA, 64Cu-TETA, 64Cu-DOTA, 64Cu-CB-TE2A

Cholecystokinin B/gastrin receptor (CCK2/CCK-B)CCK/gastrinMedullary thyroid cancer 18F-SFB, 68Ga-DOTA, 64Cu-DOTA

Glucagon-like peptide-1 receptor (GLP-1)ExendinInsulinoma cancer 18F-FBEM, 68Ga-DOTA

Neurotensin receptor (NTR1)NeurotensinSmall cell lung cancer, colon cancer, and so forth 68Ga-DOTA
18F-FB

Neuropeptide Y receptor (Y1)NPYBreast cancer, prostate cancer 64Cu-DOTA

Luteinizing hormone-releasing hormone receptor (LHRH-R)LHRHProstate cancer, breast cancer, and so forth 68Ga-DOTA

Neurokinin 1 receptor (NK-1)Substance PGlioblastoma

Vasoactive intestinal peptide receptor (VIP-R)Vasoactive intestinal peptide (VIP)Prostate cancer 64Cu-DOTA
18F-FB

Pituitary adenylate cyclase-activating peptide (PACAP) receptorPituitary adenylate cyclase-activating peptide (PACAP)Breast cancer 64Cu-DOTA

Chemokine receptor 4 (CXCR4)CXCR4Lymphatic system, lung cancer, and so forth 18F-SFB, 68Ga-DOTA, 64Cu-DOTA