- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 843657, 11 pages
Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, No. 10 Xitoutiao, You An Men Wai, Fengtai District, Beijing 100069, China
2Nursing Department, Peking University Shougang Hospital, No. 9 Jinyuanzhuang Street, Shijingshan District, Beijing 100144, China
3Department of Neurology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Street, Xicheng District, Beijing 100050, China
4Department of Nephrology, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomenxiang, Dongcheng District, Beijing 100730, China
5Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, No. 1 Dongjiaomenxiang, Dongcheng District, Beijing 100730, China
Received 7 July 2013; Accepted 14 October 2013
Academic Editor: Georgeta Mihai
Copyright © 2013 Qian Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. E. Caballero, “Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease,” Obesity Research, vol. 11, no. 11, pp. 1278–1289, 2003.
- C. E. Tabit, W. B. Chung, N. M. Hamburg, and J. A. Vita, “Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications,” Reviews in Endocrine and Metabolic Disorders, vol. 11, no. 1, pp. 61–74, 2010.
- Y. Du, M. A. Smith, C. M. Miller, and T. S. Kern, “Diabetes-induced nitrative stress in the retina, and correction by aminoguanidine,” Journal of Neurochemistry, vol. 80, no. 5, pp. 771–779, 2002.
- L. Xu, G. Xun, Z. Yao et al., “Effects of generated trans-arachidonic acids on retinal capillary during nitrative stress in diabetic rats,” Ophthalmologica, vol. 222, no. 1, pp. 37–41, 2007.
- L. Gong, F.-Q. Liu, J. Wang et al., “Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation,” Biochimica et Biophysica Acta, vol. 1813, no. 6, pp. 1211–1219, 2011.
- M.-H. Zou, C. Shi, and R. A. Cohen, “High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H2 receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells,” Diabetes, vol. 51, no. 1, pp. 198–203, 2002.
- M. E. Doyle and J. M. Egan, “Mechanisms of action of glucagon-like peptide 1 in the pancreas,” Pharmacology and Therapeutics, vol. 113, no. 3, pp. 546–593, 2007.
- T. Vilsbøll and J. J. Holst, “Incretins, insulin secretion and Type 2 diabetes mellitus,” Diabetologia, vol. 47, no. 3, pp. 357–366, 2004.
- L. L. Baggio and D. J. Drucker, “Biology of Incretins: GLP-1 and GIP,” Gastroenterology, vol. 132, no. 6, pp. 2131–2157, 2007.
- D. J. Drucker and M. A. Nauck, “The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes,” Lancet, vol. 368, no. 9548, pp. 1696–1705, 2006.
- A. K. Bose, M. M. Mocanu, R. D. Carr, C. L. Brand, and D. M. Yellon, “Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury,” Diabetes, vol. 54, no. 1, pp. 146–151, 2005.
- L. A. Nikolaidis, D. Elahi, T. Hentosz et al., “Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy,” Circulation, vol. 110, no. 8, pp. 955–961, 2004.
- L. A. Nikolaidis, S. Mankad, G. G. Sokos et al., “Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion,” Circulation, vol. 109, no. 8, pp. 962–965, 2004.
- T. Nyström, M. K. Gutniak, Q. Zhang et al., “Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease,” American Journal of Physiology—Endocrinology and Metabolism, vol. 287, no. 6, pp. E1209–E1215, 2004.
- M. Yu, C. Moreno, K. M. Hoagland et al., “Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats,” Journal of Hypertension, vol. 21, no. 6, pp. 1125–1135, 2003.
- D. Lorber, “GLP-1 receptor agonists: effects on cardiovascular risk reduction,” Cardiovascular Therapeutics, 2012.
- A. Basu, N. Charkoudian, W. Schrage, R. A. Rizza, R. Basu, and M. J. Joyner, “Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride,” American Journal of Physiology—Endocrinology and Metabolism, vol. 293, no. 5, pp. E1289–E1295, 2007.
- K. Ban, M. H. Noyan-Ashraf, J. Hoefer, S.-S. Bolz, D. J. Drucker, and M. Husain, “Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways,” Circulation, vol. 117, no. 18, pp. 2340–2350, 2008.
- K. C. Dozier, E. L. Cureton, R. O. Kwan, B. Curran, J. Sadjadi, and G. P. Victorino, “Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation,” Peptides, vol. 30, no. 9, pp. 1735–1741, 2009.
- R. Gentilella, C. Bianchi, A. Rossi, and C. M. Rotella, “Exenatide: a review from pharmacology to clinical practice,” Diabetes, Obesity and Metabolism, vol. 11, no. 6, pp. 544–556, 2009.
- J. A. Lovshin and D. J. Drucker, “Incretin-based therapies for type 2 diabetes mellitus,” Nature Reviews Endocrinology, vol. 5, no. 5, pp. 262–269, 2009.
- H. Liu, A. E. Dear, L. B. Knudsen, and R. W. Simpson, “A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules,” Journal of Endocrinology, vol. 201, no. 1, pp. 59–66, 2009.
- A. Mima, J. Hiraoka-Yamomoto, Q. Li et al., “Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes,” Diabetes, vol. 61, no. 11, pp. 2967–2979, 2012.
- J. Ai, L.-H. Wang, R. Zhang et al., “Protective effect of the daming capsule on impaired baroreflexes in STZ-induced diabetic rats with hyperlipoidemia,” BMC Complementary and Alternative Medicine, vol. 10, article 80, 2010.
- W. Wang, G.-J. Zhu, and S.-Y. Zu, “Effects on 17β-estradiol and phytoestrogen α-zearalanol on tissue factor in plasma of ovariectomized rats and HUVECs,” Chinese Journal of Physiology, vol. 47, no. 2, pp. 67–72, 2004.
- K. Wang, J. Zhang, J. Liu et al., “Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death: Omi/HtrA2 and aged heart injury,” Age, vol. 35, no. 3, pp. 733–746, 2013.
- L. Tao, E. Gao, X. Jiao et al., “Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress,” Circulation, vol. 115, no. 11, pp. 1408–1416, 2007.
- Q. Fan, X.-C. Yang, Y. Liu et al., “Postconditioning attenuates myocardial injury by reducing nitro-oxidative stress in vivo in rats and in humans,” Clinical Science, vol. 120, no. 6, pp. 251–261, 2011.
- P. P. Zhen, Q. Zhao, D. D. Hou, et al., “Genistein attenuates vascular endothelial impairment in ovariectomized hyperhomocysteinemic rats,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 730462, 10 pages, 2012.
- S. Lillioja, D. M. Mott, M. Spraul et al., “Insulin resistance and insulin secretory dysfunction as precursors of non- insulin-dependent diabetes mellitus: prospective studies of Pima Indians,” The New England Journal of Medicine, vol. 329, no. 27, pp. 1988–1992, 1993.
- M. Alemany, “Utilization of dietary glucose in the metabolic syndrome,” Nutrition and Metabolism, vol. 8, no. 1, pp. 74–83, 2011.
- R. R. S. Costa, N. R. Villela, M. D. G. C. Souza et al., “High fat diet induces central obesity, insulin resistance and microvascular dysfunction in hamsters,” Microvascular Research, vol. 82, no. 3, pp. 416–422, 2011.
- S. N. Murthy, R. C. Hilaire, D. B. Casey et al., “The synthetic GLP-I receptor agonist, exenatide, reduces intimal hyperplasia in insulin resistant rats,” Diabetes and Vascular Disease Research, vol. 7, no. 2, pp. 138–144, 2010.
- R. Kodera, K. Shikata, H. U. Kataoka et al., “Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes,” Diabetologia, vol. 54, no. 4, pp. 965–978, 2011.
- M. D'Amico, C. Di Filippo, R. Marfella et al., “Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice,” Experimental Gerontology, vol. 45, no. 3, pp. 202–207, 2010.