Comparative Analyses of the β-Tubulin Gene and Molecular Modeling Reveal Molecular Insight into the Colchicine Resistance in Kinetoplastids Organisms

Table 2

Structure comparison of the β-tubulin model of L. (V.) guyanensis and Bos taurus.

	L. (V.) guyanensis	Bos taurus
PDB Code	—	1Z2B
Number of residues	426	418
Sequence identity with L. (V.) guyanensis	—	84%
msd C𝛼 versus L. (V.) guyanensis	—	2.01 Å; (418 C𝛼 atoms)
Total area Å^2	18592.2	16732.0
(Total volume Å^3)	(36286.5)	(36262.4)
%Phi/Psi^¶	78.6	73.3

PDB: Protein Data Bank code; rmsd: root-mean-square deviation; C_𝛼: α carbon. ¶Phi and Psi are torsion angle of the all residues of the L. (V.) guyanensis chain, %Phi/Psi: Phi-Psi combination in favourable regions of the Ramachandran plot, 𝑍-score: −8.87.