- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Annual Issues
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 845816, 9 pages
http://dx.doi.org/10.1155/2013/845816
A New Dual-Promoter System for Cardiomyocyte-Specific Conditional Induction of Apoptosis
1Gruppo Intini-SMA Laboratory of Experimental Cardiology, Institute of Life Sciences, Scuola Superiore Sant’Anna, 56127 Pisa, Italy
2Retrovirus Centre and Virology Section, Department of Translational Research, University of Pisa, 56127 Pisa, Italy
3Molecular Medicine Laboratory, International Centre for Genetic Engineering and Biotechnology, Padriciano, 34149 Trieste, Italy
4Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Received 2 October 2012; Accepted 13 December 2012
Academic Editor: Decheng Yang
Copyright © 2013 Silvia Agostini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- R. S. Hotchkiss, A. Strasser, J. E. McDunn, and P. E. Swanson, “Mechanisms of disease: cell death,” The New England Journal of Medicine, vol. 361, no. 16, pp. 1570–1583, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Narula, N. Haider, R. Virmani et al., “Apoptosis in myocytes in end-stage heart failure,” The New England Journal of Medicine, vol. 335, no. 16, pp. 1182–1189, 1996. View at Publisher · View at Google Scholar · View at Scopus
- G. Olivetti, R. Abbi, F. Quaini et al., “Apoptosis in the failing human heart,” The New England Journal of Medicine, vol. 336, no. 16, pp. 1131–1141, 1997. View at Publisher · View at Google Scholar · View at Scopus
- D. Cesselli, I. Jakoniuk, L. Barlucchi et al., “Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy,” Circulation Research, vol. 89, no. 3, pp. 279–286, 2001. View at Scopus
- D. Wencker, M. Chandra, K. Nguyen et al., “A mechanistic role for cardiac myocyte apoptosis in heart failure,” Journal of Clinical Investigation, vol. 111, no. 10, pp. 1497–1504, 2003. View at Publisher · View at Google Scholar · View at Scopus
- S. Yamamoto, G. Yang, D. Zablocki et al., “Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy,” Journal of Clinical Investigation, vol. 111, no. 10, pp. 1463–1474, 2003. View at Publisher · View at Google Scholar · View at Scopus
- M. J. Everly, “Cardiac transplantation in the United States: an analysis of the UNOS registry,” Clinical Transplants, pp. 35–43, 2008. View at Scopus
- A. Pfeifer, T. Lim, and K. Zimmermann, “Lentivirus transgenesis,” Methods in Enzymology, vol. 477, pp. 3–15, 2010. View at Publisher · View at Google Scholar · View at Scopus
- S. Elmore, “Apoptosis: a review of programmed cell death,” Toxicologic Pathology, vol. 35, no. 4, pp. 495–516, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. A. Susin, H. K. Lorenzo, N. Zamzami et al., “Molecular characterization of mitochodrial apoptosis-inducing factor,” Nature, vol. 397, no. 6718, pp. 441–446, 1999. View at Publisher · View at Google Scholar · View at Scopus
- C. Delettre, V. J. Yuste, R. S. Moubarak et al., “AIFsh, a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer,” Journal of Biological Chemistry, vol. 281, no. 10, pp. 6413–6427, 2006. View at Publisher · View at Google Scholar · View at Scopus
- L. Vannucci, F. Chiuppesi, F. di Martino, M. A. Caligo, G. Bevilacqua, and M. Pistello, “Feline immunodeficiency virus vector as a tool for preventative strategies against human breast cancer,” Veterinary Immunology and Immunopathology, vol. 134, no. 1-2, pp. 132–137, 2010. View at Publisher · View at Google Scholar · View at Scopus
- F. Chiuppesi, L. Vannucci, A. De Luca et al., “A lentiviral vector-based, herpes simplex virus 1 (HSV-1) glycoprotein B vaccine affords cross-protection against HSV-1 and HSV-2 genital infections,” Journal of Virology, vol. 86, pp. 6563–6574, 2012.
- M. Campan, V. Lionetti, G. D. Aquaro et al., “Ferritin as a reporter gene for in vivo tracking of stem cells by 1. 5-T cardiac MRI in a rat model of myocardial infarction,” American Journal of Physiology, vol. 300, pp. H2238–H2250, 2011.
- S. Gascón, J. A. Paez-Gomez, M. Díaz-Guerra, P. Scheiffele, and F. G. Scholl, “Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons,” Journal of Neuroscience Methods, vol. 168, no. 1, pp. 104–112, 2008. View at Publisher · View at Google Scholar · View at Scopus
- W. C. Claycomb, N. A. Lanson, B. S. Stallworth et al., “HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 6, pp. 2979–2984, 1998. View at Publisher · View at Google Scholar · View at Scopus
- J. Vargas Jr., G. L. Gusella, V. Najfeld, M. E. Klotman, and A. Cara, “Novel integrase-defective lentiviral episomal vectors for gene transfer,” Human Gene Therapy, vol. 15, no. 4, pp. 361–372, 2004. View at Publisher · View at Google Scholar · View at Scopus
- K. V. Barnes, G. Cheng, M. M. Dawson, and D. R. Menick, “Cloning of cardiac, kidney, and brain promoters of the feline ncx1 gene,” Journal of Biological Chemistry, vol. 272, no. 17, pp. 11510–11517, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. Pistello, L. Vannucci, A. Ravani et al., “Streamlined design of a self-inactivating feline immunodeficiency virus vector for transducing ex vivo dendritic cells and T lymphocytes,” Genetic Vaccines and Therapy, vol. 5, article 8, 2007. View at Publisher · View at Google Scholar · View at Scopus
- D. Bonci, A. Cittadini, M. V. G. Latronico et al., “'Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo,” Gene Therapy, vol. 10, no. 8, pp. 630–636, 2003. View at Publisher · View at Google Scholar · View at Scopus
- C. J. Lee, X. Fan, X. Guo, and J. A. Medin, “Promoter-specific lentivectors for long-term, cardiac-directed therapy of Fabry disease,” Journal of Cardiology, vol. 57, no. 1, pp. 115–122, 2011. View at Publisher · View at Google Scholar · View at Scopus
- S. L. Semple-Rowland, W. E. Coggin, M. Geesey et al., “Expression characteristics of dual-promoter lentiviral vectors targeting retinal photoreceptors and müller cells,” Molecular Vision, vol. 16, pp. 916–934, 2010. View at Scopus
- P. Kumar and C. Woon-Khiong, “Optimization of lentiviral vectors generation for biomedical and clinical research purposes: contemporary trends in technology development and applications,” Current Gene Therapy, vol. 11, no. 2, pp. 144–153, 2011. View at Publisher · View at Google Scholar · View at Scopus
- K. Stieger, B. Belbellaa, C. Le Guiner, P. Moullier, and F. Rolling, “In vivo gene regulation using tetracycline-regulatable systems,” Advanced Drug Delivery Reviews, vol. 61, no. 7-8, pp. 527–541, 2009. View at Publisher · View at Google Scholar · View at Scopus
- N. C. Weber, O. Toma, H. Damla, J. I. Wolter, W. Schlack, and B. Preckel, “Upstream signaling of protein kinase C-ε in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1,” European Journal of Pharmacology, vol. 539, no. 1-2, pp. 1–9, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. A. Dixon and F. G. Spinale, “Large animal models of heart failure; A critical link in the translation of basic science to clinical practice,” Circulation, vol. 2, no. 3, pp. 262–271, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. W. Peng, L. Pham, H. Ye et al., “Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors,” Gene Therapy, vol. 8, no. 19, pp. 1456–1463, 2001. View at Publisher · View at Google Scholar · View at Scopus