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BioMed Research International
Volume 2013 (2013), Article ID 846387, 9 pages
Molecular Profiling Predicts the Existence of Two Functionally Distinct Classes of Ovarian Cancer Stroma
1Integrated Cancer Research Center, School of Biology and Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Dr., Atlanta, GA 30332, USA
2Ovarian Cancer Institute, 960 Johnson Ferry Road, Suite 130, Atlanta, GA 30342, USA
Received 6 March 2013; Revised 16 April 2013; Accepted 18 April 2013
Academic Editor: Tao Huang
Copyright © 2013 Loukia N. Lili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- L. A. Liotta and E. C. Kohn, “The microenvironment of the tumour—host interface,” Nature, vol. 411, no. 6835, pp. 375–379, 2001.
- N. A. Bhowmick and H. L. Moses, “Tumor-stroma interactions,” Current Opinion in Genetics and Development, vol. 15, no. 1, pp. 97–101, 2005.
- T. D. Tlsty and L. M. Coussens, “Tumor stroma and regulation of cancer development,” Annual Review of Pathology, vol. 1, pp. 119–150, 2006.
- D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000.
- A. A. Kamat, M. Fletcher, L. M. Gruman et al., “The clinical relevance of stromal matrix metalloproteinase expression in ovarian cancer,” Clinical Cancer Research, vol. 12, no. 6, pp. 1707–1714, 2006.
- L. Zhang, N. Yang, J. W. Park et al., “Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer,” Cancer Research, vol. 63, no. 12, pp. 3403–3412, 2003.
- C. Porcile, A. Bajetto, F. Barbieri et al., “Stromal cell-derived factor-1α (SDF-1α/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation,” Experimental Cell Research, vol. 308, no. 2, pp. 241–253, 2005.
- E. Wang, Y. Ngalame, M. C. Panelli et al., “Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer,” Clinical Cancer Research, vol. 11, no. 1, pp. 113–122, 2005.
- P. Micke and A. Östman, “Tumour-stroma interaction: cancer-associated fibroblasts as novel targets in anti-cancer therapy?” Lung Cancer, vol. 45, supplement 2, pp. S163–S175, 2004.
- A. Silva, A. Gírio, I. Cebola, C. I. Santos, F. Antunes, and J. T. Barata, “Intracellular reactive oxygen species are essential for PI3K/Akt/mTOR-dependent IL-7-mediated viability of T-cell acute lymphoblastic leukemia cells,” Leukemia, vol. 25, no. 6, pp. 960–967, 2011.
- C. Schroten, N. F. Dits, E. W. Steyerberg et al., “The additional value of TGFβ1 and IL-7 to predict the course of prostate cancer progression,” Cancer Immunology, Immunotherapy, vol. 61, no. 6, pp. 905–910, 2012.
- M. A. A. Al-Rawi, R. E. Mansel, and W. G. Jiang, “Interleukin-7 (IL-7) receptor (IL-7R) signalling complex in human solid tumours,” Histology and Histopathology, vol. 18, no. 3, pp. 911–923, 2003.
- M. J. Maeurer, W. Walter, D. Martin et al., “Interleukin-7 (IL-7) in colorectal cancer: IL-7 is produced by tissues from colorectal cancer and promotes preferential expansion of tumour infiltrating lymphocytes,” Scandinavian Journal of Immunology, vol. 45, no. 2, pp. 182–192, 1997.
- N. A. Bhowmick, E. G. Neilson, and H. L. Moses, “Stromal fibroblasts in cancer initiation and progression,” Nature, vol. 432, no. 7015, pp. 332–337, 2004.
- C. Jin, F. Wang, X. Wu, C. Yu, Y. Luo, and W. L. McKeehan, “Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors,” Cancer Research, vol. 64, no. 13, pp. 4555–4562, 2004.
- N. Turner and R. Grose, “Fibroblast growth factor signalling: from development to cancer,” Nature Reviews Cancer, vol. 10, no. 2, pp. 116–129, 2010.
- T. Reya and H. Clevers, “Wnt signalling in stem cells and cancer,” Nature, vol. 434, no. 7035, pp. 843–850, 2005.
- T. D. Bui, M. Lako, S. Lejeune et al., “Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25,” Gene, vol. 189, no. 1, pp. 25–29, 1997.
- S. Yoshioka, M. L. King, S. Ran et al., “WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway,” Molecular Cancer Research, vol. 10, no. 3, pp. 469–482, 2012.
- A. B. Tchagang, A. H. Tewfik, M. S. DeRycke, K. M. Skubitz, and A. P. N. Skubitz, “Early detection of ovarian cancer using group biomarkers,” Molecular Cancer Therapeutics, vol. 7, no. 1, pp. 27–37, 2008.
- A. Ricken, P. Lochhead, M. Kontogiannea, and R. Farookhi, “Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs,” Endocrinology, vol. 143, no. 7, pp. 2741–2749, 2002.
- D. Hanahan and R. A. Weinberg, “Hallmarks of cancer: the next generation,” Cell, vol. 144, no. 5, pp. 646–674, 2011.
- A. Nowicki, J. Szenajch, G. Ostrowska et al., “Impaired tumor growth in colony-stimulating factor 1 (CSF-1)-deficient, macrophage-deficient op/op mouse: evidence for a role of CSF-1-dependent macrophages in formation of tumor stroma,” International Journal of Cancer, vol. 65, no. 1, pp. 112–119, 1996.
- G. Pawelec, “Tumour escape: antitumour effectors too much of a good thing?” Cancer Immunology, Immunotherapy, vol. 53, no. 3, pp. 262–274, 2004.
- L. Yang and D. P. Carbone, “Tumor-host immune interactions and dendritic cell dysfunction,” Advances in Cancer Research, vol. 92, pp. 13–27, 2004.
- L. M. Coussens and Z. Werb, “Inflammation and cancer,” Nature, vol. 420, no. 6917, pp. 860–867, 2002.
- R. Kalluri and M. Zeisberg, “Fibroblasts in cancer,” Nature Reviews Cancer, vol. 6, no. 5, pp. 392–401, 2006.
- S. Gillessen, Y. N. Naumov, E. E. S. Nieuwenhuis et al., “CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 15, pp. 8874–8879, 2003.
- T. A. Gonda, A. Varro, T. C. Wang, and B. Tycko, “Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?” Seminars in Cell and Developmental Biology, vol. 21, no. 1, pp. 2–10, 2010.
- J. A. Parrott, E. Nilsson, R. Mosher et al., “Stromal-epithelial interactions in the progression of ovarian cancer: influence and source of tumor stromal cells,” Molecular and Cellular Endocrinology, vol. 175, no. 1-2, pp. 29–39, 2001.