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BioMed Research International
Volume 2013 (2013), Article ID 846725, 10 pages
http://dx.doi.org/10.1155/2013/846725
Research Article

Rotenone Upregulates Alpha-Synuclein and Myocyte Enhancer Factor 2D Independently from Lysosomal Degradation Inhibition

1Laboratory of Neurobiology, Department of Surgery and Interdisciplinary Medicine, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
2PhD Program in Neuroscience, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
3Department of Neurology, San Gerardo Hospital, Via Pergolesi 33, 20900 Monza, Italy

Received 5 April 2013; Revised 18 June 2013; Accepted 2 July 2013

Academic Editor: Michelangelo Mancuso

Copyright © 2013 Gessica Sala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. M. Cuervo, L. Stafanis, R. Fredenburg, P. T. Lansbury, and D. Sulzer, “Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy,” Science, vol. 305, no. 5688, pp. 1292–1295, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. S. K. Mak, A. L. McCormack, A. B. Manning-Bog, A. M. Cuervo, and D. A. Di Monte, “Lysosomal degradation of α-synuclein in vivo,” Journal of Biological Chemistry, vol. 285, no. 18, pp. 13621–13629, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. A. M. Cuervo and J. F. Dice, “Regulation of Lamp2a levels in the lysosomal membrane,” Traffic, vol. 1, no. 7, pp. 570–583, 2000. View at Scopus
  4. A. M. Cuervo and J. F. Dice, “Unique properties of lamp2a compared to other lamp2 isoforms,” Journal of Cell Science, vol. 113, no. 24, pp. 4441–4450, 2000. View at Scopus
  5. R. Kiffin, C. Christian, E. Knecht, and A. M. Cuervo, “Activation of chaperone-mediated autophagy during oxidative stress,” Molecular Biology of the Cell, vol. 15, no. 11, pp. 4829–4840, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Xilouri, T. Vogiatzi, K. Vekrellis, D. Park, and L. Stefanis, “Abberant α-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy,” PLoS ONE, vol. 4, no. 5, Article ID e5515, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Alvarez-Erviti, M. C. Rodriguez-Oroz, J. M. Cooper et al., “Chaperone-mediated autophagy markers in Parkinson disease brains,” Archives of Neurology, vol. 67, no. 12, pp. 1464–1472, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. P. D. Smith, M. P. Mount, R. Shree et al., “Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2,” Journal of Neuroscience, vol. 26, no. 2, pp. 440–447, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. Q. Yang, H. She, M. Gearing et al., “Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy,” Science, vol. 323, no. 5910, pp. 124–127, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. H. She, Q. Yang, K. Shepherd et al., “Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients,” Journal of Clinical Investigation, vol. 121, no. 3, pp. 930–940, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Marin and E. Aguilar, “In vivo 6-OHDA-induced neurodegeneration and nigral autophagic markers expression,” Neurochemistry International, vol. 58, no. 4, pp. 521–526, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. B.-Y. Cao, Y.-P. Yang, W.-F. Luo et al., “Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway,” Journal of Ethnopharmacology, vol. 131, no. 1, pp. 122–129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. M.-K. Kim, S.-C. Kim, J.-I. Kang et al., “6-hydroxydopamine-induced PC12 cell death is mediated by MEF2D down-regulation,” Neurochemical Research, vol. 36, no. 2, pp. 223–231, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Sala, L. Brighina, E. Saracchi et al., “Vesicular monoamine transporter 2 mRNA levels are reduced in platelets from patients with Parkinson's disease,” Journal of Neural Transmission, vol. 117, no. 9, pp. 1093–1098, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. T. B. Sherer, P. A. Trimmer, K. Borland, J. K. Parks, J. P. Bennett Jr., and J. B. Tuttle, “Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells,” Brain Research, vol. 891, no. 1-2, pp. 94–105, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Giordano, J. Lee, V. M. Darley-Usmar, and J. Zhang, “Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death,” PLoS ONE, vol. 7, Article ID e44610, 2012.
  17. Y. N. Deng, J. Shi, J. Liu, and Q. M. Qu, “Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy,” Neurochemistry International, vol. 63, pp. 1–9, 2013.
  18. K. A. Malkus and H. Ischiropoulos, “Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration,” Neurobiology of Disease, vol. 46, no. 3, pp. 732–744, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Betarbet, T. B. Sherer, G. MacKenzie, M. Garcia-Osuna, A. V. Panov, and J. T. Greenamyre, “Chronic systemic pesticide exposure reproduces features of Parkinson's disease,” Nature Neuroscience, vol. 3, no. 12, pp. 1301–1306, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Betarbet, R. M. Canet-Aviles, T. B. Sherer et al., “Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system,” Neurobiology of Disease, vol. 22, no. 2, pp. 404–420, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. S. V. Kalivendi, D. Yedlapudi, C. J. Hillard, and B. Kalyanaraman, “Oxidants induce alternative splicing of α-synuclein: implications for Parkinson's disease,” Free Radical Biology and Medicine, vol. 48, no. 3, pp. 377–383, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. R. E. Musgrove, A. E. King, and T. C. Dickson, “α-synuclein protects neurons from apoptosis downstream of free-radical production through modulation of the MAPK signalling pathway,” Neurotoxicity Research, vol. 23, pp. 358–369, 2013.
  23. H.-J. Kim, B. S. Jeon, M.-Y. Yoon, S.-S. Park, and K.-W. Lee, “Increased expression of alpha-synuclein by SNCA duplication is associated with resistance to toxic stimuli,” Journal of Molecular Neuroscience, vol. 47, no. 2, pp. 249–255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Chen, E. McMillan-Ward, J. Kong, S. J. Israels, and S. B. Gibson, “Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species,” Journal of Cell Science, vol. 120, no. 23, pp. 4155–4166, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. R. A. González-Polo, M. Niso-Santano, M. A. Ortíz-Ortíz et al., “Inhibition of paraquat-induced autophagy accelerates the apoptotic cell death in neuroblastoma SH-SY5Y cells,” Toxicological Sciences, vol. 97, no. 2, pp. 448–458, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Filomeni, I. Graziani, D. de Zio et al., “Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease,” Neurobiology of Aging, vol. 33, no. 4, pp. 767–785, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Yao, W. Li, H. She et al., “Activation of transcription factor MEF2D by bis(3)-cognitin protects dopaminergic neurons and ameliorates parkinsonian motor defects,” Journal of Biological Chemistry, vol. 287, pp. 34246–34255, 2012.
  28. L. Alvarez-Erviti, Y. Seow, A. H. Schapira et al., “Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission,” Neurobiology of Disease, vol. 42, no. 3, pp. 360–367, 2011. View at Publisher · View at Google Scholar · View at Scopus