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BioMed Research International
Volume 2013 (2013), Article ID 847069, 5 pages
Clinical Study

First Evidence of Increased Plasma Serotonin Levels in Tako-Tsubo Cardiomyopathy

1Inserm, Metabolic and Cardiovascular Disease Institute of Rangueil, 31432 Toulouse, France
2Paul Sabatier University, 31062 Toulouse, France
3Department of Pharmacy, University Hospital Center, 31059 Toulouse, France
4Department of Cardiology, University Hospital of Rangueil, 1 avenue Jean Poulhès, 31059 Toulouse, France
5Department of Pharmacology, Faculty of Medicine Paris-Ouest, 78000 Versailles St-Quentin-en-Yvelines, France
6Department of Biology, Pharmacology Unit, General Hospital of Versailles, 78150 Le Chesnay, France
7Cardiac Imaging Center, University Hospital Center, 31059 Toulouse, France
8Department of Nuclear Medicine, University Hospital Center, 31059 Toulouse, France

Received 9 April 2013; Revised 6 August 2013; Accepted 12 August 2013

Academic Editor: Amedeo Chiribiri

Copyright © 2013 C. Rouzaud Laborde et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS). Methods and Results. Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS ( , versus control; , versus control; and  ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI ( ). Conclusion. This finding suggests that serotonin could participate to the pathophysiology of TTC.