First Evidence of Increased Plasma Serotonin Levels in Tako-Tsubo Cardiomyopathy

Table 1

Characteristics of healthy control subjects and patients with ST elevation myocardial infarction and Tako-Tsubo cardiomyopathy.

	Healthy control subject	ST elevation myocardial infarction	Tako-Tsubo cardiomyopathy	𝑃 value
	𝑛=14	𝑛=14	𝑛=14
Age (years)	62±6	70±14	64±11	0.12
Female (𝑛 (%))	5 (35)	12 (86)	12 (86)	0.48
Body mass index (kg/m^2)	26.1±0.9	26.4±5.1	24.3±4.5	0.4
LVEF (%)	66±2	47±2	42±3	<0.0001
Cardiovascular risk factors (𝑛 (%))
Current smoking	2 (14)	3 (21)	2 (14)	0.99
Previous smoking	4 (28)	1 (7)	6 (43)	0.10
Hypertension	3 (21)	11 (79)	7 (50)	0.01
Diabetes	1 (7)	3 (21)	1 (7)	0.59
Hyperlipidemia	4 (28)	8 (57)	6 (43)	0.27
Obesity	0	6 (43)	5 (36)	0.02
Creatinine clearance (mL/min)	96±6	77±22	104±32	0.02
Psychiatric diagnosis (𝑛 (%))
Current or past major depressive disorder	4 (28)	3 (21)	10 (71)	0.02
Generalized anxiety disorder	0	0	6 (43)	0.001
Biological samples
Troponin peak (ng/mL)	NA	124±125	3±3	0.002
Hemoglobin (g/dL)	14.3±0.3	12.3±1.3	12.0±3.8	0.001
Platelets counts (1000/mL)	210±10	251±79	262±106	<0.0001

Proportions are tested by Fisher’s exact test or 𝜒² test as appropriate (effective ≤5 or >5, resp.), and quantitative values are tested by analysis of variance (ANOVA test).
LVEF: Left ventricular ejection fraction.