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BioMed Research International
Volume 2013 (2013), Article ID 849321, 5 pages
Clinical Study

Interaction between a Regenerative Matrix and Wound Bed in Nonhealing Ulcers: Results with 16 Cases

1Department of Dermatology, Macchi Foundation Hospital, Viale Borri 57, Varese, Italy
2Zucchi Clinical Institute, Via Zucchi 24, Monza, Italy
3Department of Histopathology, University of Insubria, Via Rossi 9, Varese, Italy
4Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Via Dunant 3, Varese, Italy

Received 29 May 2013; Accepted 26 June 2013

Academic Editor: Davide Vigetti

Copyright © 2013 Alberico Motolese et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A chronic wound is a wound that is delayed in one of the wound-healing stages and cannot progress any further. A chronic wound leaves the patient at risk of infection and hospitalization. In these case series, 16 patients affected by venous ulcers underwent Hyalomatrix PA grafting for reconstructive surgery. Hyalomatrix PA is a bilayered, sterile, flexible, and conformable three-dimensional matrix made of fibers of HYAFF, a benzyl ester of hyaluronic acid, and a semipermeable silicone membrane. Hyalomatrix PA acts as a substitutive and regenerative permanent matrix able to replace the dermis providing a three-dimensional matrix for cellular invasion and capillary growth. The silicon layer controls water vapor loss avoiding an excessive loss of fluids and acts as a semipermeable barrier to the external agents. In the presented cases, the average area grafted per procedure was 153 cm2. The length of followup ranged from 0.5 to 1 year. The final results were considered to be good in 12 cases, fair in 3 cases, and poor in one case. This study suggests that the combination of wound bed preparation with application of the hyaluronic regenerative matrix can be a valid approach for treatment of partial thickness ulcers.