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BioMed Research International
Volume 2013 (2013), Article ID 849321, 5 pages
http://dx.doi.org/10.1155/2013/849321
Clinical Study

Interaction between a Regenerative Matrix and Wound Bed in Nonhealing Ulcers: Results with 16 Cases

1Department of Dermatology, Macchi Foundation Hospital, Viale Borri 57, Varese, Italy
2Zucchi Clinical Institute, Via Zucchi 24, Monza, Italy
3Department of Histopathology, University of Insubria, Via Rossi 9, Varese, Italy
4Department of Experimental and Clinical Biomedical Sciences, University of Insubria, Via Dunant 3, Varese, Italy

Received 29 May 2013; Accepted 26 June 2013

Academic Editor: Davide Vigetti

Copyright © 2013 Alberico Motolese et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Falanga and W. H. Eaglstein, “The “trap” hypothesis of venous ulceration,” The Lancet, vol. 341, no. 8851, pp. 1006–1008, 1993. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Takase, L. Pascarella, L. Lerond, J. J. Bergan, and G. W. Schmid-Schönbein, “Venous hypertension, inflammation and valve remodeling,” European Journal of Vascular and Endovascular Surgery, vol. 28, no. 5, pp. 484–493, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. M. Loots, E. N. Lamme, J. Zeegelaar, J. R. Mekkes, J. D. Bos, and E. Middelkoop, “Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds,” Journal of Investigative Dermatology, vol. 111, no. 5, pp. 850–857, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. H. J. Wallace and M. C. Stacey, “Levels of tumor necrosis factor-α (TNF-α) and soluble TNF receptors in chronic venous leg ulcers—correlations to healing status,” Journal of Investigative Dermatology, vol. 110, no. 3, pp. 292–296, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. R. W. Tarnuzzer and G. S. Schultz, “Biochemical analysis of acute and chronic wound environments,” Wound Repair and Regeneration, vol. 4, no. 3, pp. 321–325, 1996. View at Scopus
  6. N. J. Trengove, S. R. Langton, and M. C. Stacey, “Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers,” Wound Repair and Regeneration, vol. 4, no. 2, pp. 234–239, 1996. View at Scopus
  7. M. V. Mendez, A. Stanley, H.-Y. Park, K. Shon, T. Phillips, and J. O. Menzoian, “Fibroblasts cultured from venous ulcers display cellular characteristics of senescence,” Journal of Vascular Surgery, vol. 28, no. 5, pp. 876–883, 1998. View at Scopus
  8. R. J. Snyder, “Treatment of nonhealing ulcers with allografts,” Clinics in Dermatology, vol. 23, no. 4, pp. 388–395, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. W. Y. J. Chen and G. Abatangelo, “Functions of hyaluronan in wound repair,” Wound Repair and Regeneration, vol. 7, no. 2, pp. 79–89, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Harding, Clinical Challenges and Promises of HYAFF Technology in Wound Healing Redefining Hyaluronan, Elsevier BV, 2000.
  11. R. D. Price, V. Das-Gupta, I. M. Leigh, and H. A. Navsaria, “A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model,” Tissue Engineering, vol. 12, no. 10, pp. 2985–2995, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. G. Gravante, D. Delogu, N. Giordan, G. Morano, A. Montone, and G. Esposito, “The use of hyalomatrix PA in the treatment of deep partial-thickness burns,” Journal of Burn Care and Research, vol. 28, no. 2, pp. 269–274, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Caravaggi, F. Grigoletto, and N. Scuderi, “Wound bed preparation with a dermal substitute (hyalomatrix PA) facilitates re-epithelialization and healing: results of a multicenter, prospective, observational study on complex chronic ulcers (the FAST study),” Wounds, vol. 23, no. 8, pp. 228–235, 2011. View at Scopus
  14. C. Dowsett and E. Ayello, “TIME principles of chronic wound bed preparation and treatment,” British Journal of Nursing, vol. 13, no. 15, pp. S16–23, 2004. View at Scopus
  15. A. Asari, “Novel Functions of Hyaluronan Oligosaccharides,” Science of Hyaluronan Today, February 2005, http://www.glycoforum.gr.jp/science/hyaluronan/hyaluronanE.html.
  16. A. Passi, P. Sadeghi, H. Kawamura et al., “Hyaluronan suppresses epidermal differentiation in organotypic cultures of rat keratinocytes,” Experimental Cell Research, vol. 296, no. 2, pp. 123–134, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Jiang, J. Liang, and P. W. Noble, “Hyaluronan as an immune regulator in human diseases,” Physiological Reviews, vol. 91, no. 1, pp. 221–264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Galassi, P. Brun, M. Radice et al., “In vitro reconstructed dermis implanted in human wounds: degradation studies of the HA-based supporting scaffold,” Biomaterials, vol. 21, no. 21, pp. 2183–2191, 2000. View at Scopus