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BioMed Research International
Volume 2013 (2013), Article ID 849492, 7 pages
http://dx.doi.org/10.1155/2013/849492
Research Article

An Influence of Immunomodulation on Th1 and Th2 Immune Response in Endometriosis in an Animal Model

1Department of Mother’s and Child’s Health, K. Marcinkowski University of Medical Sciences, Polna Street 33, 60-535 Poznań, Poland
2Department of Perinatology and Gynecology, K. Marcinkowski University of Medical Sciences, Polna Street 33, 60-535 Poznań, Poland
3Department of Cell Biology, K. Marcinkowski University of Medical Sciences, Rokietnicka 5D Street, 60-806 Poznań, Poland
4The Scientific Research Enterprise RESAN, Street Tolstogo 1, 210026 Vitebsk, Belarus
5Department of Toxicology, Laboratory of Environmental Studies, K. Marcinkowski University of Medical Sciences, Dojazd 30 Street, 60-631 Poznań, Poland
6Department of Obstetrics and Gynecology, Medical University of Wroclaw, Ul. M. Curie-Skłodowskiej 58, 50-369 Wroclaw, Poland
7Department of Biology and Preservation of Environment, K. Marcinkowski University of Medical Sciences, Ul. Długa 1/2, 61-848 Poznań, Poland

Received 24 June 2013; Revised 5 September 2013; Accepted 10 September 2013

Academic Editor: Kaei Nasu

Copyright © 2013 K. Szymanowski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To assess the role of the Th1 and Th2 cellular response in the etiology of endometriosis observed in a rat model, with the use of the RESAN immunomodulator. Materials and Methods. A comparative analysis of cytokines in blood serum typical of Th1 (TNF-α and INF-γ) and Th2 (IL-4, IL-6, IL-10) cell response in groups of rats, in which RESAN preparation was used as prophylaxis (Gr. I) or treatment (Gr. II) of endometriosis. Results. The results indicated an increase in the level of cytokines in blood serum typical of Th2 cell response by comparing the second and third stages of the experiment in the second group of rats and a decrease in IL-4 and IL-10 between III and IV stages. There was a significant difference in cytokine levels during the third stage of the experiment by comparing I and II groups of rats. In the III group of rats, levels of IL-10 significantly increased between the II and III stages of the experiment. Conclusion. RESAN preparation shows Th2 cell response, inhibiting the development of endometriosis in a rat model. Due to successful prophylactic action, one may speculate that RESAN vaccine may be effective as a complementary treatment after surgical excision.