Research Article

Correlation of N-Acetyltransferase 2 Genotype with Isoniazid Acetylation in Polish Tuberculosis Patients

Table 1

The INH concentration at 3 hours after drug administration among various NAT2 genotypes.

GenotypeNumber%INH (µg/mL)AUC0–6

NAT2*4/*475,41,2 ± 0,68,55 ± 4,6
wt/wt71,2 ± 0,68,55 ± 4,6
NAT2*4/*52519,22,3 ± 1,215,7 ± 6,2
NAT2*4/*613102,1 ± 1,414,7 ±6,3
NAT2*4/*710,81,215
wt/m39302,2 ± 1,315,4 ± 6,1
NAT2*5/*52216,94,1 ± 1,223,5 ± 6,1
NAT2*5/*64534,64,2 ± 1,524,5 ± 7,6
NAT2*6/*6107,74,4 ± 1,025,9 ± 5,8
NAT2*6/*753,84,6 ± 1,725,9 ± 7,8
NAT2*7/*721,57,7 ± 1,144,1 ± 7,1
m/m8464,64,4 ± 1,525,0 ± 7,5

AUC0–6: area under the concentration curve during the period of 0–6 hours