Correlation of N-Acetyltransferase 2 Genotype with Isoniazid Acetylation in Polish Tuberculosis Patients

Table 2

Pharmacokinetic parameters of INH in plasma among fast, intermediate, and slow acetylators by the chromatographic method.

Genotype of acetylation	Pharmacokinetic parameters of INH
	I 3	C 6	𝐾𝑒	T 0,5	C max	AUC0–6	AUCtotal
Fast	0,36^a	0,27^a	0,51^b	1,59^a	3,39^a	8,6^a	9,2^a
Intermediate	0,55^a	0,70^a	0,41^b	1,85^a	5,80^b	15,4^b	17,5^b
Slow	0,97^b	2,20^b	0,27^a	3,14^b	7,09^c	24,5^c	35,5^c

The different letters in the columns indicate significant differences (at 𝑃≤0.05) between the respective types of acetylation.
I ₃: index of acetylation.
C ₆: concentration of INH 6 hours after drug administration.
𝐾_𝑒: fixed speed of elimination 1/h.
T _0,5: elimination half time.
AUC_0–6: area under concentration curve in the period 0–6 hours.
AUC_total: area under concentration curve.