Coagulation Proteins Influencing Global Coagulation Assays in Cirrhosis: Hypercoagulability in Cirrhosis Assessed by Thrombomodulin-Induced Thrombin Generation Assay

Table 2

Multivariate regression analysis of the determinants of global coagulation tests in cirrhosis (𝑛=156).

		PT	aPTT	Lag time		Peak thrombin		ETP
	SD			5 pM TF	1 pM TF	5 pM TF	1 pM TF	5 pM TF	1 pM TF
		𝛽	𝛽	𝛽	𝛽	𝛽	𝛽	𝛽	𝛽
(Adjusted 𝑅^2)		0.779	0.633	0.491	0.394	0.509	0.348	0.465	0.265
Fibrinogen	111.9	0.092	−0.005	0.640^†	0.602^†	0.032	−0.219*	−0.044	−0.200
FII	33.7	−0.413*	−0.659*	−0.311	−0.434	0.455*	0.005	1.339^†	0.427
FV	22.6	−0.146*	0.027	0.166*	0.106	0.123	0.015	0.000	−0.081
FVII	39.1	−0.297^†	0.089	−0.241	−0.004	0.051	0.127	−0.233	0.098
FVIII	60.6	0.038	−0.179	0.029	0.102	−0.047	−0.083	0.133	−0.097
FIX	35.3	−0.291*	−0.680^†	−0.145	−0.281	0.614^†	0.990^†	0.183	0.717^†
FX	34.4	−0.150	0.507*	−0.210	−0.216	0.077	0.265	0.233	0.119
Antithrombin	53.6	0.041	−0.088	0.023	0.026	0.001	−0.057	−0.227*	−0.158
Protein C	44.4	0.301*	−0.025	0.364*	0.466*	−0.657^†	−0.846^†	−0.796^†	−1.093^†
Protein S	25.8	0.019	−0.041	0.281^†	0.256*	0.019	−0.121	−0.099	−0.027

Data are expressed as standardized regression coefficients (𝛽). *P < 0.05; ^†P < 0.001.
F: factor; PT: prothrombin time; aPTT: activated partial thromboplastin time; ETP: endogenous thrombin potential; TF: tissue factor.