Research Article

Treatment with Anti-Interleukin 23 Antibody Ameliorates Disease in Lupus-Prone Mice

Figure 1

A monoclonal anti-IL-23p19 antibody limits the IL-23-induced production of IL-17 by MRL/lpr splenocytes. One million MRL/lpr splenocytes were activated in vitro in the presence of plate bound anti-CD3 and anti-CD28 antibodies (see Section 2). IL-23 was added in the medium as indicated at a concentration of 10 ng/mL. At 24 hours later, the concentration of IL-17 was measured in the supernatants using ELISA. Asterisk ( ) signifies statistical significance.
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