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Clinical data | Patients |
P1 (R.A.) | P2 (G.K.) | P3 (M.S.) | P4 (G.A.) | P5 (P.R.A.) |
|
Age (years) | 39 | 40 | 21 | 31 | 39 |
FSH (IU/L) | 89.1 | 65.8 | 11.8 | 162.0 | 67.8 |
LH (IU/L) | 23.3 | 23.4 | 10.1 | 59.0 | 37.8 |
Prolactin (mg/L) | 12 | 4.6 | 16.4 | 9.3 | / |
Estradiol (nmol/L) | <0.073 | 0.08 | 0.2 | / | / |
Inhibin B (ng/L) | <10 | <10 | 52.4 | >10 | / |
S-AMH (mg/L) | 0.00 | 0.00 | 0.89 | 0.00 | / |
Karyotype | Abnormal (mosaic 45X, 47XXX, 48XXXX, 46XX) | Normal (no FMR1-fragile X mutation)
| Normal (no FMR1-fragile X mutation)
| Normal (no FMR1-fragile X mutation)
| Normal (no FMR1-fragile X mutation)
|
Ovarian cortex histology | Inclusion cysts, corpora albicantia, focal ovarian surface epithelium, no follicles or oocytes | Inclusion cysts, corpora albicantia, simple or stratified ovarian surface epithelium, no follicles or oocytes | Simple columnar ovarian surface epithelium, several primordial follicles
| Simple cuboidal ovarian surface epithelium, corpus luteum in regression, no follicles or oocytes | Simple cuboidal ovarian surface epithelium, no follicles or oocytes |
Antiovarian antibodies | No | No | Yes | Yes | No |
Premature ovarian failure (POF) | Secondary (previous birth of a child), irregularities of menstrual cycles, thin endometrium | Primary (no children), irregular menstrual cycles, thin endometrium
| Primary (no children), irregular menstrual cycles, thin endometrium
| Primary (no children), amenorrhea, small left ovary, thin endometrium | Secondary (pregnancy ended in spontaneous abortion), amenorrhea, thin endometrium |
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