Table 1: Clinical data of all five patients with POF included into this study, which were documented at the Department of Obstetrics and Gynecology, University Medical Centre Ljubljana. All patients had increased serum levels of gonadotropins FSH (normal: <11.3 IU/L) and LH (normal: <11.6 IU/L) and thin endometrium.

Clinical dataPatients
P1
(R.A.)
P2
(G.K.)
P3
(M.S.)
P4
(G.A.)
P5
(P.R.A.)

Age (years) 39 40 21 31 39
FSH (IU/L) 89.1 65.8 11.8 162.0 67.8
LH (IU/L) 23.3 23.4 10.1 59.0 37.8
Prolactin (mg/L) 12 4.6 16.4 9.3 /
Estradiol (nmol/L) <0.073 0.08 0.2 / /
Inhibin B (ng/L) <10 <10 52.4 >10 /
S-AMH (mg/L) 0.00 0.00 0.89 0.00 /
KaryotypeAbnormal
(mosaic 45X, 47XXX, 48XXXX, 46XX)
Normal
(no FMR1-fragile X mutation)
Normal
(no FMR1-fragile X mutation)
Normal
(no FMR1-fragile X mutation)
Normal
(no FMR1-fragile X mutation)
Ovarian cortex histologyInclusion cysts, corpora albicantia, focal ovarian surface epithelium, no follicles or oocytesInclusion cysts, corpora albicantia, simple or stratified ovarian surface epithelium, no follicles or oocytesSimple columnar ovarian surface epithelium, several primordial follicles
Simple cuboidal ovarian surface epithelium, corpus luteum in regression, no follicles or oocytesSimple cuboidal ovarian surface epithelium,
no follicles or oocytes
Antiovarian antibodies NoNoYesYesNo
Premature ovarian failure (POF)Secondary (previous birth of a child), irregularities of menstrual cycles, thin endometriumPrimary
(no children), irregular menstrual cycles, thin endometrium
Primary
(no children), irregular menstrual cycles, thin endometrium
Primary
(no children), amenorrhea, small left ovary, thin endometrium
Secondary (pregnancy ended in spontaneous abortion),
amenorrhea, thin endometrium