Hyperpolarization-Activated Current, , in Mathematical Models of Rabbit Sinoatrial Node Pacemaker Cells
Figure 2
State diagrams of the channel used in mathematical models of the hyperpolarization-activated current in rabbit sinoatrial node pacemaker cells. (a) Two-state model with a first-order Hodgkin and Huxley type gate. The channel flips between its open state O and closed state C at rates and . (b) Hodgkin and Huxley type model with two identical gates. (c) Three-state equivalent of the state diagram of (b). (d) Five-state model, with two closed states (C1 and C2) and three open states (O1, O2, and O3), as used in the mathematical model of a rabbit sinoatrial node pacemaker cell by Sarai et al. [78].
