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BioMed Research International
Volume 2013 (2013), Article ID 872739, 10 pages
http://dx.doi.org/10.1155/2013/872739
Research Article

Assessment of Respiration-Induced Motion and Its Impact on Treatment Outcome for Lung Cancer

1Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, China
2Department of Radiation Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
3Department of Nuclear Physics, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
4Department of Radiation Oncology, The First People’s Hospital of Foshan City, Foshan 528800, China
5Department of Radiation Oncology, The First People’s Hospital of Jining City, Jining 272011, China

Received 5 March 2013; Revised 18 April 2013; Accepted 25 April 2013

Academic Editor: An Liu

Copyright © 2013 Yan Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study presented the analysis of free-breathing lung tumor motion characteristics using GE 4DCT and Varian RPM systems. Tumor respiratory movement was found to be associated with GTV size, the superior-inferior tumor location in the lung, and the attachment degree to rigid structure (e.g., chest wall, vertebrae, or mediastinum), with tumor location being the most important factor among the other two. Improved outcomes in survival and local control of 43 lung cancer patients were also reported. Consideration of respiration-induced motion based on 4DCT for lung cancer yields individualized margin and more accurate and safe target coverage and thus can potentially improve treatment outcome.