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BioMed Research International
Volume 2013 (2013), Article ID 876314, 14 pages
http://dx.doi.org/10.1155/2013/876314
Research Article

Influenza Virus Specific CD8+ T Cells Exacerbate Infection Following High Dose Influenza Challenge of Aged Mice

1Wistar Institute, Philadelphia, PA 19104, USA
2Drexel University, Philadelphia, PA 19104, USA
3Columbia University, New York, NY 10027, USA
4Graduate Group of the University of Pennsylvania, Philadelphia, PA 19104, USA
5Cheyney University, Thornbury Township, PA 19139, USA
6Boehringer Ingelheim GMBH, Ridgefield, CT D6877, USA
7Department of Microbiology and Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA

Received 3 April 2013; Revised 3 June 2013; Accepted 4 June 2013

Academic Editor: Kelvin To

Copyright © 2013 E. M. Parzych et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8+ T cells. Here we assess the effect of a potent antiviral CD8+ T cell response on influenza virus infection of young and aged mice. Our results show that CD8+ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.