Table 3: Some of genes significantly overexpressed in oocytes according to [15, 16] and GeneCards data.

Genes significantly overexpressed in oocytes
Gene symbolGene titleChromosome

Gamete markers
DAZL Deleted in azoospermia-like3
DDX4/VASA DEAD (Asp-Glu-Ala-Asp) box polypeptide 45
DPPA3/STELLA Developmental pluripotency associated 312

Embryogenesis, pluripotency, self-renewal, proliferation, development
ZAR1 Zygote arrest 14
PUM1 Pumilio homolog 1 (Drosophila)1
PUM2 Pumilio homolog 2 (Drosophila)2
NANOS1 Nanos homolog 1 (Drosophila)10
NANOG Nanog homeobox12
SOX2 SRY (sex determining region Y)-box 2 3
SALL2 Sal-like 2 (Drosophila)14
KLF4 Kruppel-like factor 4 (gut) 9
LIN28B Lin-28 homolog B (C. elegans) 6

Maturation promoting and related factors
CCNB1 Cyclin B15
CCNB2 Cyclin B215
CDC2/CDK1 Cell division cycle 2, G1 to S and G2 to M10
CDC25A Cell division cycle 25A3
CDC25B Cell division cycle 25B20
CDC25C Cell division cycle 25C5

Spindle checkpoint
BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog2
BUB1B/BUBR1 BUB1 budding uninhibited by benzimidazoles 1 homolog beta15
CENPA Centromere protein A2
CENPE Centromere protein E4
CENPH Centromere protein H5
MAD2L1/MAD2 MAD2 mitotic arrest deficient-like 14

Cytoplasmic receptors
NALP5/NLRP5/MATER NLR family, pyrin domain containing 519

APC/C complex, securin, cohesins
ANAPC1/APC1 Anaphase promoting complex subunit 12
ANAPC10/APC10 Anaphase promoting complex subunit 104
CDC20 CDC20 cell division cycle 201
PTTG1 Pituitary tumor-transforming 15
PTTG3 Pituitary tumor-transforming 3 (meiosis)8
STAG3 Stromal antigen 3 (meiosis)7

Epigenetic remodeling
DNMT1 DMA (cytosine-5-)-methyltransferase 119
DNMT3B DMA (cytosine-5-)-methyltransferase 3 beta20
HDAC9 Histone deacetylase 97
H1FOO H1 histone family, member O, oocyte-specific3
HCAP-G Chromosome condensation protein G4

Meiosis, miscellaneous
AKAP1 A kinase (PRKA) anchor protein 117
MCM3 MCM3 minichromosome maintenance deficient 36
MOS v-mos Moloney murine sarcoma viral oncogene homolog8
REC8 REC8 homolog (yeast)14
STAG3 Stromal antigen 3 7
FMN2 Formin 2 1
SYCP1 Synaptonemal complex protein 1 1
SYCP2 Synaptonemal complex protein 2 20
SYCP3 Synaptonemal complex protein 312
SMC3 Structural maintenance of chromosomes 310
SMC1B Structural maintenance of chromosomes 1B22
STRA8 Stimulated by retinoic acid gene 8 homolog (mouse)7
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)3
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 22
PELO Pelota homolog (Drosophila) 5
WEE2 WEE1 homolog 2 (S. pombe) 7
SGOL2 Shugoshin-like 2 (S. pombe) 2
PPP2CA Protein phosphatase 2, catalytic subunit, alpha isozyme 5
SPAG16 Sperm associated antigen 16 2
TUBB4Q Tubulin, beta polypeptide 4, member Q 4
FBXO5/EMI1 F-box protein 5 6
AURKC Aurora kinase C 19

Extracellular matrix, growth factors, cell surface, signaling
BMP15 Bone morphogenetic protein 15 X
BMP6 Bone morphogenetic protein 6 6
GDF9 Growth differentiation factor 9 5
FGFR2 Fibroblast growth factor receptor 2 10
FGF9 Fibroblast growth factor 9 (glia-activating factor) 13
FGF14 Fibroblast growth factor 14 13
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4
IL4 Interleukin 4 5
TNFSF13/APRIL Tumor necrosis factor superfamily, member 13 v-erb-a erythroblastic leukemia viral oncogene 17
ERBB4 Homolog 4 2
FZD3 Frizzled homolog 3 8
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 7
GPR39 G protein-coupled receptor 39 2
GPR51 G protein-coupled receptor 51 9
GPR126 G protein-coupled receptor 126 6
GPR143 G protein-coupled receptor 143 X
GPR160 G protein-coupled receptor 160 3
ZP1 Zona pellucida glycoprotein 1 (sperm receptor) 11
ZP2 Zona pellucida glycoprotein 2 (sperm receptor) 16
ZP3 Zona pellucida glycoprotein 3 (sperm receptor) 7
ZP4 Zona pellucida glycoprotein 4 1
SLC5A11 Solute carrier family 5 (sodium/glucose cotransporter), member 11 16
SOCS7 Suppressor of cytokine signaling 7 17

Transcription factors, oogenesis, folliculogenesis
FIGLA Folliculogenesis specific basic helix-loop-helix 2
POU5F1 POU class 5 homeobox 1 6
NOBOX NOBOX oogenesis homeobox 7
BNC1 Basonuclin 1 15
GCNF/NR6A1 Nuclear receptor subfamily 6, group A, member 1 9
SOX15 SRY (sex determining region Y)-box 15 17
SOX30 SRY (sex determining region Y)-box 30 5
OTX2 Orthodenticle homolog 2 (Drosophila) 14
FOXR1 Forkhead box R1 11
JARID2 Jumonji, AT rich interactive domain 2 6

Chromatin reprogramming
NPM2 Nucleophosmin/nucleoplasmin 28

Postreplicative DNA mismatch repair system
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)2

Oolema receptor (oocyte-sperm adhesion)
ASTL Astacin-like metalloendopeptidase (M12 family) 2

Imprinted genes
MEST Mesoderm specific transcript homolog 7

Apoptosis
BNIP1 BCL2/adenovirus E1B 19 kDa interacting protein 1 5
BIRC5 Baculoviral IAP repeat-containing 5 (survivin) 17
BCL2L10 BCL2-like 10 (apoptosis facilitator) 15