Table 6: Genes which were differently expressed in human oocytes matured in vitro in comparison with oocytes matured in vivo at a cut-off value of 10-fold or higher [26, 27].

Genes differently expressed in oocytes matured
in vitro or in vivo [27]
Significantly up-regulated genes in oocytes matured in vitro Significantly down-regulated genes in oocytes matured in vitro

HNRNPA2B1, TCEB1, HINT1, PNPLA1, PAOX, NLRP12, KIF23, PRPF38B, UBA52, GEM, MBD4, MORF4L2, ATF2, AFF4, ZCCHC14, ZNF669, CCNG2, NFE2L2,  MSH2 *, ZNF610, C21orf66, CDC37L1, UPF3B, TAOK3, GPR64, HSPA14, C18orf24, TAF1A, MAP2K7,  ZNF571,  PFKFB2, CUL1, CLDN10, CLK1, RCOR1, ZPBP2, GTF2H2, TSG101, ARHGAP11A, HPS3, GRHL1, EIF4G2, RFC4, VPS26A, PIK3C2A, GDI2, RAB23, WDSOF1, PLCL1, DCDC2, MINPP1, PTPN12, METAP2, LHX8, LOC91664,
SYCP2 *, ATP5L, ICK, FUCA1, SMARCAD1,  BRD7, TBPL1, ABCD3, SSR3, FEZ2, FHOD3,  AMD1,  DAZL *, ZMYM2, FANCL, SLCO1A2,  NUFIP1, STAU2, PCF11, PPP1R3C, POLI,  SGOL2 *, PBLD, CCNL1, SLBP, MRPS30, TMOD2, FBXW11, CDK7, HNRNPR, CFDP1,  DEPDC7, CTSL2, DYNC1I2, NCKAP1, TRPA1,  DCLRE1A, RAB18, GTDC1, LOC283514, CLUL1, ZNF131, SP3, ZNF302, MAD2L1, TRAPPC6B, C10orf137, MTPN, ZNF313,  PLEKHA3, ZCCHC14, RTTN, ZNF136, ADH5, CCDC88A, CPEB2, SPATA5L1, UGP2, UGP2,MFSD1, TMEM27, ZNF443, UAP1, MIB1, MUT
HTRA1, CCDC69, FHL2

Molecular functions of differently expressed genes
(in vitro versus in vivo matured oocytes) [26]
Significantly up-regulated genes in
oocytes matured in vitro (number)
Significantly down-regulated genes in oocytes matured in vitro (number)

(i) Nucleic acid binding (62)(i) Nucleic acid binding (75)
(ii) Zinc finger transcription factor (13)(ii) Ribosomal protein (37)
(iii) Other RNA-binding factors (10)(iii) Translation factor (8)
(iv) Ligase (9)(iv) Translation elongation factor (6)
(v) KRAB box transcription factor (8)(v) Storage protein (6)
(vi) mRNA processing factor (8)(vi) Receptor (5)
(vii) Chaperone (7)(vii) Tubulin (4)
(viii) Receptor (7)(viii) Signaling molecule (3)
(ix) Signaling (7)(ix) Ribonucleoprotein (2)
(x) Ribonucleoprotein (7)(x) Defense/immunity protein (1)

Genes related to germ cells and meiosis.