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BioMed Research International
Volume 2013 (2013), Article ID 892106, 10 pages
http://dx.doi.org/10.1155/2013/892106
Review Article

Translational Potential into Health Care of Basic Genomic and Genetic Findings for Human Immunodeficiency Virus, Chlamydia trachomatis, and Human Papilloma Virus

1Institute for Public Health Genomics (IPHG), Department of Genetics and Cell Biology, Research School GROW School for Oncology & Developmental Biology, Faculty of Health, Medicine & Life Sciences, University of Maastricht, 6229 ER Maastricht, The Netherlands
2Laboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
3Department of Internal Medicine, VU University Medical Centre, 1081 HV Amsterdam, The Netherlands

Received 28 February 2013; Revised 1 May 2013; Accepted 7 May 2013

Academic Editor: Enrique Medina-Acosta

Copyright © 2013 Jelena Malogajski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Individual variations in susceptibility to an infection as well as in the clinical course of the infection can be explained by pathogen related factors, environmental factors, and host genetic differences. In this paper we review the state-of-the-art basic host genomic and genetic findings’ translational potential of human immunodeficiency virus (HIV), Chlamydia trachomatis (CT), and Human Papilloma Virus (HPV) into applications in public health, especially in diagnosis, treatment, and prevention of complications of these infectious diseases. There is a significant amount of knowledge about genetic variants having a positive or negative influence on the course and outcome of HIV infection. In the field of Chlamydia trachomatis, genomic advances hold the promise of a more accurate subfertility prediction test based on single nucleotide polymorphisms (SNPs). In HPV research, recent developments in early diagnosis of infection-induced cervical cancer are based on methylation tests. Indeed, triage based on methylation markers might be a step forward in a more effective stratification of women at risk for cervical cancer. Our review found an imbalance between the number of host genetic variants with a role in modulating the immune response and the number of practical genomic applications developed thanks to this knowledge.