About this Journal Submit a Manuscript Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 896536, 6 pages
http://dx.doi.org/10.1155/2013/896536
Research Article

Vitamin C Intake Reduces the Cytotoxicity Associated with Hyperglycemia in Prediabetes and Type 2 Diabetes

1PPG em Promoção da Saúde, Universidade de Santa Cruz do Sul, Avenida Independência, 2293, Sala 4206, 96815-900 Santa Cruz do Sul, RS, Brazil
2Curso de Nutrição/DEDFIS, Universidade de Santa Cruz do Sul, Santa Cruz do Sul, RS, Brazil
3Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

Received 10 April 2013; Revised 18 June 2013; Accepted 23 June 2013

Academic Editor: Norma Possa Marroni

Copyright © 2013 Silvia Isabel Rech Franke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Maiese, S. D. Morhan, and Z. C. Zhao, “Oxidative stress biology and cell injury during Type 1 and Type 2 diabetes mellitus,” Current Neurovascular Research, vol. 4, no. 1, pp. 63–71, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. R. Singh, A. Barden, T. Mori, and L. Beilin, “Advanced glycation end-products: a review,” Diabetologia, vol. 44, no. 2, pp. 129–146, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Jakuš and N. Rietbrock, “Advanced glycation end-products and the progress of diabetic vascular complications,” Physiological Research, vol. 53, no. 2, pp. 131–142, 2004. View at Scopus
  4. R. C. Ruhe and R. B. McDonald, “Use of antioxidant nutrients in the prevention and treatment of Type 2 diabetes,” Journal of the American College of Nutrition, vol. 20, supplement 5, pp. S363–S383, 2001. View at Scopus
  5. T. L. Duarte and J. Lunec, “Review: when is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C,” Free Radical Research, vol. 39, no. 7, pp. 671–686, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Fenech and A. A. Morley, “Measurement of micronuclei in lymphocytes,” Mutation Research, vol. 147, no. 1-2, pp. 29–36, 1985. View at Scopus
  7. S. W. Maluf, “Monitoring DNA damage following radiation exposure using cytokinesis-block micronucleus method and alkaline single-cell gel electrophoresis,” Clinica Chimica Acta, vol. 347, no. 1-2, pp. 15–24, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Fenech, “Cytokinesis-block micronucleus cytome assay,” Nature Protocols, vol. 2, no. 5, pp. 1084–1104, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Prá, A. Bortoluzzi, L. L. Müller et al., “Iron intake, red cell indicators of iron status, and DNA damage in young subjects,” Nutrition, vol. 27, no. 3, pp. 293–297, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. IOM and Institute of Medicine, Dietary Reference Intakes For Vitamin C, Vitamin E, Selenium, and Carotenoids, Food and Nutrition Board, National Academy Press, Washington, DC, USA, 2000.
  11. J. Varvarovska, J. Racek, R. Stetina et al., “Aspects of oxidative stress in children with Type 1 diabetes mellitus,” Biomedicine & Pharmacotherapy, vol. 58, no. 10, pp. 539–545, 2004.
  12. J. Blasiak, M. Arabski, R. Krupa et al., “DNA damage and repair in type 2 diabetes mellitus,” Mutation Research, vol. 554, no. 1-2, pp. 297–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Lodovici, L. Giovannelli, V. Pitozzi, E. Bigagli, G. Bardini, and C. M. Rotella, “Oxidative DNA damage and plasma antioxidant capacity in type 2 diabetic patients with good and poor glycaemic control,” Mutation Research, vol. 638, no. 1-2, pp. 98–102, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Afkhami-Ardekani and A. Shojaoddiny-Ardekani, “Effect of vitamin C on blood glucose, serum lipids and serum insulin in type 2 diabetes patients,” Indian Journal of Medical Research, vol. 126, no. 5, pp. 471–474, 2007. View at Scopus
  15. S. W. Choi, I. Benzie, C. S. Y. Lam et al., “Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus,” Diabetic Medicine, vol. 22, no. 10, pp. 1347–1353, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Fenech, “The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis,” Mutagenesis, vol. 20, no. 4, pp. 255–269, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. C. M. Sena, E. Nunes, A. Gomes et al., “Supplementation of coenzyme Q10 and α-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats,” Nutrition Research, vol. 28, no. 2, pp. 113–121, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. A. C. Carr and B. Frei, “Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans,” American Journal of Clinical Nutrition, vol. 69, no. 6, pp. 1086–1107, 1999. View at Scopus
  19. M. Koga, M. Otsuki, S. Matsumoto, H. Saito, M. Mukai, and S. Kasayama, “Negative association of obesity and its related chronic inflammation with serum glycated albumin but not glycated hemoglobin levels,” Clinica Chimica Acta, vol. 378, no. 1-2, pp. 48–52, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. P. Yates and I. Laing, “Age-related increase in haemoglobin A1c and fasting plasma glucose is accompanied by a decrease in β cell function without change in insulin sensitivity: evidence from a cross-sectional study of hospital personnel,” Diabetic Medicine, vol. 19, no. 3, pp. 254–258, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Adaikalakoteswari, M. Rema, V. Mohan, and M. Balasubramanyam, “Oxidative DNA damage and augmentation of poly(ADP-ribose) polymerase/nuclear factor-kappa B signaling in patients with Type 2 diabetes and microangiopathy,” International Journal of Biochemistry and Cell Biology, vol. 39, no. 9, pp. 1673–1684, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. B. Bagatini, R. P. Palazzo, M. T. Rodrigues, C. H. Costa, and S. W. Maluf, “Induction and removal of DNA damage in blood leukocytes of patients with type 2 diabetes mellitus undergoing hemodialysis,” Mutation Research, vol. 657, no. 2, pp. 111–115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. C. S. Pereira, P. Molz, R. P. Palazzo et al., “DNA damage and cytotoxicity in adult subjects with prediabetes,” Mutation Research, vol. 753, no. 2, pp. 76–81, 2013.
  24. S. K. Shettigar, C. Shailaja, and R. K. Kulkarni, “Elevated micronuclei frequency in type 2 diabetes with high glycosylated hemoglobin,” Diabetes Research and Clinical Practice, vol. 95, no. 2, pp. 246–250, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Otton, F. G. Soriano, R. Verlengia, and R. Curi, “Diabetes induces apoptosis in lymphocytes,” Journal of Endocrinology, vol. 182, no. 1, pp. 145–156, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Pazdro and J. R. Burgess, “The role of vitamin E and oxidative stress in diabetes complications,” Mechanisms of Ageing and Development, vol. 131, no. 4, pp. 276–286, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. S. I. R. Franke, D. Prá, J. Da Silva, B. Erdtmann, and J. A. P. Henriques, “Possible repair action of Vitamin C on DNA damage induced by methyl methanesulfonate, cyclophosphamide, FeSO4 and CuSO4 in mouse blood cells in vivo,” Mutation Research, vol. 583, no. 1, pp. 75–84, 2005. View at Publisher · View at Google Scholar · View at Scopus