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BioMed Research International
Volume 2013 (2013), Article ID 901740, 7 pages
http://dx.doi.org/10.1155/2013/901740
Clinical Study

No Association of IFNG+874T/A SNP and NOS2A-954G/C SNP Variants with Nitric Oxide Radical Serum Levels or Susceptibility to Tuberculosis in a Brazilian Population Subset

1Immunology and Immunogenetics Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, Brazil
2Department of Genetics and Southwest National Primate Research Center, Texas Biomedical Research Institute, 7620 NW Loop 410, 78227-5301 San Antonio, TX, USA
3Tuberculosis Clinical Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Avenida Brasil 4365, Manguinhos, 21045-900 Rio de Janeiro, RJ, Brazil

Received 1 April 2013; Revised 5 June 2013; Accepted 5 July 2013

Academic Editor: Helder I. Nakaya

Copyright © 2013 Ana Cristina C. S. Leandro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberculosis (TB) is one of the most common infectious diseases in the world. Mycobacterium tuberculosis infection leads to pulmonary active disease in approximately 5–10% of exposed individuals. Both bacteria- and host-related characteristics influence latent infection and disease. Host genetic predisposition to develop TB may involve multiple genes and their polymorphisms. It was reported previously that interferon gamma (IFN-γ) and nitric oxide synthase 2 (NOS2) are expressed on alveolar macrophages from TB patients and are responsible for bacilli control; thus, we aimed this study at genotyping single nucleotide polymorphisms IFNG+874T/A SNP and NOS2A-954G/C SNP to estimate their role on TB susceptibility and determine whether these polymorphisms influence serum nitrite and production. This case-control study enrolled 172 TB patients and 179 healthy controls. Neither polymorphism was associated with susceptibility to TB. NOS2A-954G/C SNP was not associated with serum levels of nitrite and . These results indicate that variants of IFNG+874T/A SNP and NOS2A-954G/C SNP do not influence TB susceptibility or the secretion of nitric oxide radicals in the study population.