No Association of IFNG+874T/A SNP and NOS2A-954G/C SNP Variants with Nitric Oxide Radical Serum Levels or Susceptibility to Tuberculosis in a Brazilian Population Subset
Table 2
Distribution of genotypes and alleles frequencies of the IFNG+874T/A and NOS2A-954G/C SNPs in tuberculosis patients and control groups.
Genotype/allele
Tuberculosis patients (%)
Control group (%)
OR
TB latent infection (TST+) (%)
OR
A/A
72 (41.8)
62 (34.6)
0.21
1.00
38 (38.8)
0.76
1.00
A/T
78 (45.3)
91 (50.8)
0.74
48 (49.0)
0.86
T/T
22 (12.8)
26 (14.6)
0.73
12 (12.2)
0.77
T/T+A/T versus A/A
100 (58.1)
117 (65.3)
0.16
0.74 (0.47–1.16)
60 (61.2)
0.61
0.88 (0.51–1.51)
T/T versus A/A+A/T
150 (87.2)
153 (85.4)
0.63
0.86 (0.45–1.66)
86 (87.8)
0.89
1.05 (0.47–2.38)
Alleles
A
222 (64.5)
215 (60.1)
0.22
1.21 (0.88–1.66)
124 (63.3)
0.76
1.06 (0.72–1.55)
T
122 (35.5)
143 (39.9)
72 (36.7)
G/G
152 (88.4)
160 (89.4)
0.77
1.00
84 (85.7)
0.78
1.00
G/C
19 (11.0)
18 (10.0)
1.11
13 (14.3)
0.81
C/C
1 (0.6)
1 (0.6)
1.05
0
NA
C/C versus G/C+G/G
171 (99.4)
178 (99.4)
0.97
1.04 (0.0–38.36)
97 (100)
0.45
—
G/G versus C/C+G/C
20 (11.6)
19 (10.6)
0.76
0.90 (0.44–1.84)
13 (13.3)
0.67
1.18 (0.52–2.63)
Alleles
G
323 (93.9)
338 (94.4)
0.76
0.91
183 (93.4)
0.80
1.09
C
21 (6.1)
20 (5.6)
(0.46–1.66)
13 (6.6)
(0.50–2.35)
value considered ; OR, odds ratio value from TB patients and control group. value from TB patients and control TST-positive subgroup. TST+: tuberculin skin test positive.
